OBJECTIVE To explore the relationship between serum neuron-specific enolase (NSE) levels and diabetic neuropathy. RESEARCH DESIGN AND METHODS Type 1 or 2 diabetic and healthy control subjects (n = 568) were randomly enrolled in a cross-sectional study. Diabetic neuropathy status was documented by the presence of clinical symptoms or signs, electromyography, quantitative sensory tests, and car...

BACKGROUND The molecular mechanisms behind diabetic neuropathy remains to be investigated. METHODS This is a secondary study on microarray dataset (GSE24290) downloaded from Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI), which included 18 nerve tissue samples of progressing diabetic neuropathy (fibers loss ≥500 fibers/mm) and 17 nerve tissue samples...

background: considering the dramatic increasing rate of diabetes and consequently its related complications, most importantly diabetic peripheral neuropathy (dpn), challenges regarding proper treatment of dpn and its effect on the quality-of-life and care of diabetic patients, the aim of this current study is to evaluate the effect of intradermal botulinum toxin type a (btx-a) injections on pai...

Human diabetic neuropathy is multifactorial in etiology, with ischemia as a final common pathology. Although impaired vascular endothelial cell function in diabetic microvascular injury is established, the role of thrombomodulin (TM)-dependent protein C antithrombotic mechanism in the pathogenesis of neuropathy is unclear. This neuropathologic case-control study investigated whether vascular en...

OBJECTIVE To determine the prevalence of sub clinical diabetic neuropathy in Saudi diabetics and the risk factors associated with symptomatic diabetic neuropathy. METHODS A prospective study of Saudi diabetics attending King Abdulaziz University Hospital out patient clinic from January 1998 until April 1999. Detailed information of each patients` age, sex, body mass index, type and duration o...

Objective: To compare the pedobarographic findings of plantar pressure distribution in individuals with typical diabetic neuropathy non-diabetic individuals. Methods: 25 patients were randomly selected and another electively. After undergoing clinical examination according to report recommendations San Antonio Conference on Diabetic Neuropathy, glycated hemoglobin (HbA1c) static podobarography ...

BACKGROUND We investigated the prevalence of diabetic autonomic neuropathy (DAN) and vestibular dysfunction (VD) in diabetic patients with peripheral neuropathy. METHODS Thirty-five diabetic patients with peripheral neuropathy were enrolled from August 2008 to July 2009. All subjects underwent autonomic function tests. Nineteen of the patients (54.3%) underwent videonystagmography. RESULTS ...

BACKGROUND Peripheral neuropathy is a major contributor to diabetic foot complications including ulceration, sepsis and limb loss. The aim of this study was to document the frequency of this previously undocumented clinical marker of peripheral neuropathy, the "slipping slipper sign" (SSS), characterised by unrecognised loss of slippers from one's feet while walking, and to compare it with trad...

Diabetic foot ulcers and infections are common complications of diabetic disease. Additionally, these a cause morbidity impose substantial burden to the patient society. It is imperative understand major contributing factors, namely, neuropathy, peripheral arterial disease, immune system dysfunction in order guide treatment. Management disease begins with detailed history thorough physical exam...