Gene expression data analysis is playing a vital role in diagnosing the diseases and drug designing. Many researchers realized that most of the cancers could be diagnosed based on the gene expression data. This paper focusses on identifying the prominent genes, which are mainly causing the Leukemia cancer using computational methods. Clustering methods are used to identify the components of a d...

INTRODUCTION Acute leukemia is rare in pregnancy. The importance of promptly diagnosing and treating this disease in pregnancy stems from its life-threatening potential, both to the mother and fetus. CASE PRESENTATION We report a case of relapse of acute myeloid leukemia at 23 weeks of pregnancy in a 24-year-old Albanian woman. Our patient categorically refused chemotherapy treatment, and in ...

Monoclonal B-cell lymphocytosis (MBL) is a recently described medical condition that displays biological similarities to the most common subtype of adult leukemia in the Western world, i.e. chronic lymphocytic leukemia (CLL). Diagnostic criteria have been published with the aim of differentiating between these two entities. The overall prevalence of MBL is at least 100 times higher than that of...

Immunophenotype is critical for diagnosing common B-cell acute lymphoblastic leukemia (common ALL) and detecting minimal residual disease. We developed a protocol to explore the immunophenotypic profiles of common ALL based on the expression levels of the antigens associated with B lymphoid development, including IL-7Rα (CD127), cytoplasmic CD79a (cCD79a), CD19, VpreB (CD179a), and sIgM, which ...

BACKGROUND Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy...

Fifty cases of acute leukemia were analyzed by means of flow cytometry. The results obtained were correlated with morphology and routine cytochemistries. The panel selected was useful in classifying an acute leukemia as acute lymphocytic (ALL) or acute nonlymphocytic (ANLL), which is of primary importance for therapeutic considerations. Common ALL (CALLA) (J5) was a good marker for classifying ...

Hybrid fuzzy expert systems are one of the most practical intelligent paradigm of soft computing techniques with the high potential for managing uncertainty associated to the medical diagnosis. The potential of genetic algorithm (GA) by inspiring from natural evolution as a learning and optimization technique has been vastly concentrated for improving fuzzy expert systems. In this paper, the GA...

Prevalensi kanker pada anak semakin meningkat. Terdapat 90 pasien leukemia yang dirawat di RS Wahidin Sudirohusodo selama tahun 2013-2017. Diagnosis morfologi akut dibagi menjadi ALL dan AML kadang-kadang tidak sesuai dengan diagnosis flow cytometry, menunjukkan karakteristik sel ganas. Penelitian ini bertujuan untuk membandingkan hasil interpretasi aspirasi sumsum tulang imunofenotip dalam men...

Necrotizing fasciitis is a part of a spectrum of necrotizing soft tissue infections that usually follow a surgical intervention or a chronic / acute medical illness. Diagnosis is often based on symptoms which classically start within hours after an injury. There are no reports on the use of PET/CT in this condition. Sparing reports of its association in patients with malignancy (Ca of colon and...