Abstract Ionizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present soil and cosmic rays, or artificial, fuel for nuclear power plants. Overexposure to ionizing may damage living tissue could cause severe health problems (i.e., mutations, sickness, cancer, death). Cytogenetic bio-dosimetry has great advantage take into account inter-ind...

This report describes two patients with a distinctive type of dicentric autosomal chromosome formed by breakage and union between homologous chromosomes. These stable chromosomes possess two C bands, implying the presence of two centromeric regions. The first child, evaluated for dysmorphic features was shown to have an abnormal chromosome 16, designated as 46, XX, -16, + dic (16) (pter leads t...

We have studied three patients with features of Turner's syndrome, two with a 45,X/46,X,r(?) and the third with a 45,X/46,X,dic?(Y) karyotype. Because Turner's syndrome patients with a mosaic karyotype containing a Y chromosome are known to have a high risk of developing gonadal tumours, we used DNA analysis and in situ hybridisation with X and Y specific probes to identify the chromosomal orig...

Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell...

We here investigated and reported the effects of beer drinking on radiation-induced chromosome aberrations in blood lymphocytes. Human blood that was collected either before or after drinking a 700 ml beer was in vitro irradiated with 200 kVp X rays or 50 keV/microm carbon ions. The relation between the radiation dose and the aberration frequencies (fragments and dicentrics) was significantly (...

The Semipalatinsk nuclear test site area is considered to have been highly contaminated with radioactive fallout during 40 years of continuous nuclear testing. Individuals living near the nuclear test site are considered to have been exposed to both internal and external radiation. In order to assess the effects of prolonged radiation, a chromosome analysis was performed in lymphocytes from 123...

We designed a system to determine whether dicentric chromosomes in Drosophila melanogaster break at random or at preferred sites. Sister chromatid exchange in a Ring-X chromosome produced dicentric chromosomes with two bridging arms connecting segregating centromeres as cells divide. This double bridge can break in mitosis. A genetic screen recovered chromosomes that were linearized by breakage...