BACKGROUND Prescribing of diclofenac for children usually involves a dose different from commercially available strengths. This drug is available only as tablets, which can be divided only so many times before the dose obtained becomes inaccurate. In addition, children may have difficulty swallowing tablets. For these reasons, a compounding formula for a liquid dosage form is essential to ensur...

Highlights: Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. some dose body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as sodium, are standard treatments The healing process consists four stages: inflammation, soft formation, complex and remodeling. Previous stud...

OBJECTIVE To explore the mechanism by which diclofenac sodium eyedrops exert an adverse effect on the cornea. METHODS In 10 healthy Japanese volunteers, 0.1% diclofenac sodium solution was instilled into one eye 3 times daily for 2 weeks. Only vehicle was applied to the other eye. Tear samples were taken before drug treatment, at 2 weeks (on the final day of treatment), and at 4 weeks. Prosta...

BACKGROUND Nigella sativa or "Kalonji" is a naturally occurring plant in Pakistan and other countries which possesses a wide range of medicinal properties, the anti-inflammatory property being one of these. Diclofenac sodium is a commonly used anti-inflammatory drug. The purpose of this study was to compare the anti-inflammatory effect of ethanolic extract of Nigella sativa seeds with that of d...

Objective: The aim of this study was to evaluate the analgesic efficacy of preoperative versus postoperative administration of diclofenac sodium in the prevention of the postoperative pain following a lower third molar surgery. Methods: A prospective randomized clinical trial was conducted on 73 patients who underwent surgical extraction of bilateral fully impacted lower third molars. Patients ...

OBJECTIVE To compare the effectiveness of dexamethasone and diclofenac sodium eye drops in the resolution of inflammation following phacoemulsification surgery with posterior chamber intraocular lens implants. STUDY DESIGN Quasi-experimental study. PLACE AND DURATION OF STUDY Ophthalmology Department, PNS Shifa Hospital, Karachi, from June 2006 to March 2007. METHODOLOGY One hundred subje...

Diclofenac potassium is a widely used non-steroid anti-inflammatory drug which is absorbed more quickly than diclofenac sodium, Reported cases of rhabdomyolisis after only diclofenac are rare, we survey three cases in the literature. . We report a case of a 50 year-old man, chronic smoker and allergic to aspirin who developed a rhabdomyolysis associated with glossopharyngeal edema after oral ad...

OBJECTIVE The aim of this study was to compare the efficacy of oral, intra muscular and transdermal diclofenac sodium for pain treatment in patients undergoing laparoscopic cholecystectomy, and their effect on postoperative opioid consumption. METHODS Following informed consent, 90 ASA I-II patients scheduled for laparoscopic cholecystectomy were randomized into three groups. Group PO got ora...

A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme. In vivo acute anti-inflammatory activity of the final compounds 11-14 was evaluated in rat using an egg-white induced edema model of inflammation in a dose equivalent to 3 mg/Kg of diclofenac sodium. All teste...

Diclofenac sodium is a Non-Steroidal Anti-inflammatory Drug, active against relief from pain and inflammation. The main objective of this research work was to prepare Ethyl Cellulose microsphere loaded with Diclofenac and invitro drug release study. In the present study, emulsion Solvent Evaporation Method is used for preparing microsphere. The polymer (EC) and drug (Diclofenac Sodium) was diss...