'The best way to predict the future is to create it.' When we look at drugs that are used to control parasites, we see that new knowledge has been created (discovered) about their modes of action. This knowledge will allow us to predict combinations of drugs which can be used together rationally to increase the spectrum of action and to slow the development of anthelmintic resistance. In this p...

A case of loiasis diagnosed at Wankie Colliery Hospital is presented. The disease was suspected by the history of the patient and the presenting clinical signs, and it was confirmed by identification of Microfilariae loa loa in peripheral blood. The patient was successfully treated with a course of diethylcarbamazine. The paper gives a brief account of the clinical aspects of loiasis and emphas...

The effect of ivermectin or diethylcarbamazine (DEC) on Wuchereria bancrofti molting from the third to the fourth larval stage (L3 to L4) was evaluated in vitro. L3 larvae were harvested from laboratory-reared Aedes togoi 2 wk after feeding upon a microfilaremic human volunteer. The larvae were kept in an artificial medium (Franke's NI medium) with 10% human serum under an atmosphere of 5% CO2 ...

One titrimetric and two spectrophotometric methods are proposed for the determination of diethylcarbamazine citrate (DEC) in bulk drug and in formulations using potassium iodate and potassium iodide as reagent. The methods employ the well-known analytical reaction between iodate and iodide in the presence of acid. In titrimetry (method A), the drug was treated with a measured excess of thiosulf...

Diethylcarbamazine (DEC) produced an initial stimulation followed by depression of the movements of the intact worm and nerve-muscle preparation of Setaria cervi. The effective concentration of DEC was reduced to one hundredth in the nerve-muscle preparation as compared to the whole worm, suggesting that the cuticular barrier is highly effective in preventing the penetration of the drugs. The d...

Since diethylcarbamazine, the drug recommended for treatment of lymphatic filariasis, seems only partially effective against the adult worm, intense interest persists in identifying a macrofilaricidal drug for this infection. To evaluate directly in vivo the macrofilaricidal activity of repeat high-dose ivermectin, 15 men who had living adult Wuchereria bancrofti detected in the scrotal area by...

India is committed to eliminate filariasis by 2015. To achieve this goal annual mass drug administration (MDA) of diethylcarbamazine (DEC) was launched in 2004 by the Government of India1,2. According to the guidelines, DEC should be administered under supervision to all people excluding children <2 yr, pregnant women and severely ill persons (noneligible). The recommended DEC dosage is one tab...

Purpose: The aim of the present study was to develop orodispersible tablets of diethylcarbamazine citrate (an anthelmintic) for improving patient compliance, especially, those of paediatric and geriatric categories with difficulties in swallowing, with the prime objective of arriving at cost effective product by effervescent method. Methods: In the effervescent method mixture of sodium bicarbon...