conclusions all plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed. results the hydroalcoholic extract of p. alkekengi showed the most tyrosinase inhibitory effect with ic50 of 0.09 mg/ml vs. 0.38, 0.38 and 2.82 mg/ml of b. persicum, a. rosea and m. vulgare, respectively. m. vulgare exhibited uncompetitive inhibition and other p...

Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors associated with ...

linear and whorled nevoid hypermelanosis. J Eur Acad Dermatol Venereol. 2005;19:638--9. 4. Cho E, Cho SH, Lee JD. Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. Int J Dermatol. 2012;51:399--405. 5. Iijima S, Naito Y, Naito S, Uyeno K. Reticulate hyperpigmentation distributed in a zosteriform fashion: a new clinical type of hyperpigmentation. Br J Dermatol. ...

The development of blue or gray cutaneous hyperpigmentation is a rare complication of chronic imipramine therapy. Treatment options for imipramine-induced hyperpigmentation are limited but include topical retinoids, bleaching agents, and laser therapy, with varying degrees of success. We report a case in which Q-switched alexandrite laser therapy alone led to nearly complete resolution of imipr...

Background: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. It is common sequelae in acne patients. Objectives: This study aimed to investigate the psychosocial impact of acne and postinflammat...