a forty two years old woman with a history of bilateral breast augmentation for cosmetic reasons was presented for poor healing of the surgical site. tissue and periprosthetic fluid were removed from the wound site revealing an atypical lymphoid infiltrate. subsequently the patient developed axillary lymph adenopathy. excisional biopsy was performed. flow cytometry was non-diagnostic. she conti...

According to the World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues, diffuse large B-cell lymphoma comprises about 40% of adult cases of non-Hodgkin s lymphoma. It consists of the following morphological variants: 1) centroblastic (with or without multilobulated nuclei); 2) immunoblastic (>90% of immunoblasts); 3) T cell/histiocytes rich; a...

The disease we now call diffuse large B-cell lymphoma has gone by many names in the past. These have included reticulum cell sarcoma,1 diffuse histiocytic lymphoma,2 and, more recently, diffuse mixed lymphoma, diffuse large cell lymphoma, or immunoblastic lymphoma—terms from the Working Formulation.3 Early studies of therapy for patients with diffuse large B-cell lymphoma contained some patient...

primary cutaneous anaplastic large cell lymphoma is a t-cell malignancy with atypical cd30 positive lymphocytes. pseudoepitheliomatous hyperplasia is an uncommon finding in primary cutaneous anaplastic large cell lymphoma, and may mimic squamous cell carcinoma as pseudomalignancy. careful attention of a pathologist to correct diagnosis of pseudoepitheliomatous hyperplasia and its underlying cau...

BACKGROUND Multiparameter flow cytometry allows the detection of minor monoclonal B-cell populations. Using this technique combined with morphology, we were struck by the presence of minor populations of small monoclonal B cells in bone marrows of patients with diffuse large B-cell lymphoma in routine diagnostic samples and performed a systematic retrospective study. DESIGN AND METHODS Bone m...

editorial Diffuse large B-cell lymphoma of the breast: a distinct entity? The management of squamous cell carcinoma arising in the lung is markedly different than squamous cell carcinoma of the skin, cervix, or larynx. Likewise, the optimal management of diffuse large B-cell lymphoma sometimes varies by the primary site of involvement. Knowledge of the unique clinical behavior of lymphoma arisi...

a case of primary malignant non-hodgkin's lymphoma of the breast is reported. this is the first well-documented case of breast lymphoma in our institution and also in iran. the diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. there is no definite c...

Diffuse large B-cell lymphoma and follicular lymphoma are the most common non-Hodgkin lymphomas seen in adults. Follicular lymphomas are derived from germinal centers of lymphatic tissue and are composed of centrocytes and centroblasts arranged into secondary lymphoid follicles with a germinal center. Follicular lymphomas can transform into diffuse large B-cell lymphoma. Follicular lymphoma in ...

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL), which is the most common type of lymphoma. NHL comprises a group of clinically and biologically diverse diseases, which range from indolent to aggressive clinical courses. Despite treatment advances in the last three decades with the use of combination immunotherapy, a significant fraction...