Purpose To examine the usefulness of rich diffusion protocols with high b-values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models were compared with the clinical apparent diffusion coefficient (ADC). Methods Four patients were scanned using 13 b-values up to 3,000 s/mm2 and diffusion times ranging 18-52...

BACKGROUND AND PURPOSE We analyzed the temporal and spatial pattern of water diffusion changes during acute subarachnoid hemorrhage (SAH) in rat brain to identify factors contributing to the acute pathophysiology of SAH. METHODS Subarachnoid hemorrhage was remotely induced via perforation of the circle of Willis with an endovascular suture during MR imaging. A fast echo-planar imaging techniq...

BACKGROUND AND PURPOSE Apart from cases studies, little is known regarding diffusion-weighted imaging of brain lesions associated with human cerebral venous thrombosis (CVT). Our aim was to describe the initial diffusion-weighted imaging patterns observed in brain areas with MR signal changes associated with CVT and to compare them with those of follow-up imaging. METHODS The cases of nine pa...

The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent breast diffusion-weighted imaging. HER-2 expression was detected in his...

Magnetic resonance microimaging was used to measure diffusion decay over an extended b-factor range in a formalin-fixed normal prostate sample and a Gleason pattern 3+4 cancer tissue sample. The coefficients of biexponential fits to diffusion decay data from 1600 voxels of dimension 160 × 160 × 160 μm(3) in each sample were correlated with underlying epithelial and stromal compartment partial v...

Diffusion-weighted imaging (DWI) is an advanced magnetic resonance imaging technique, based on the analysis of thermallydependent movement of water molecules in the extracellular space. This method allows to examine pathological changes at the cellular level which are not visible on conventional magnetic resonance (MR). Apparent diffusion coefficient (ADC) is a mathematically calculated value i...

Decreased, renormalized, or increased values of the calculated apparent diffusion coefficient (ADC) are observed in stroke models. A quantitative description of corresponding tissue states using ADC values may be extended to include true relaxation times. A histogram-based segmentation is well suited for characterizing tissues according to specific parameter combinations irrespective of the het...

Two model-independent measures of diffusion, the apparent diffusion coefficient (ADC) and return-to-the-origin probability enhancement (R) were compared for their ability to detect tissue necrosis in RIF-1 murine tumors. Both reflect the degree of restriction experienced by the endogenous water molecules; however, the ADC is calculated from the initial linear slope of the diffusion attenuation ...

PURPOSE To assess the correlation between DWI diffusion parameters obtained using Intravoxel Incoherent Motion Method (IVIM) and histological grade of Hepatocellular carcinoma (HCC). RESULTS According to Edmondson-Steiner grade lesions were classified with grade 1 (14), grade 2 (30), grade 3 (18), and grade 4 (0). Apparent Diffusion Coefficient (ADC), perfusion fraction (fp), tissue diffusion...

Feasibility of obtaining reliable and reproducible ADC maps in rat kidneys at 7 Tesla, and the effect of renal blood flow on ADC is investigated. A spin echo DWI sequence with respiratoly gating gave reproducible ADC maps with no significant differences between right and left kidneys. ADC of cortex and medulla in readout and phase direction were higher than that in slice direction (P<O.Ol, n=12...