Microfluidic DNA biochips capable of detecting specific DNA sequences are useful in medical diagnostics, drug discovery, food safety monitoring and agriculture. They are used as miniaturized platforms for analysis of nucleic acids-based biomarkers. Binding kinetics between immobilized single stranded DNA on the surface and its complementary strand present in the sample are of interest. To achie...

In recent years, the biochip by MEMS technology has been developed. The biochip has the advantages of biocompatibility, precision, low-cost, disposable, and easy to produce etc. MEMS technology widely used in cell detection or position a single-cell level, including the mechanical, optical electromagnetic and electronic fields. This study proposal, imitate the oviduct that can effectively posit...

Apheresis is an essential step in clinical diagnostic. Searching for a safe and fast way was necessary to avoid wasting time obtain the desired results efficiently. <span lang="EN-US">This research includes two stages: First, microfluidic biochip with properties of processing response, automation capability, low-cost designed having tiny mesh-type channel that filters pure plasma from blo...

   Historically, DNA molecules have been known as the building blocks of life, later on in 1994, Leonard Adelman introduced a technique to utilize DNA molecules for a new kind of computation. According to the massive parallelism, huge storage capacity and the ability of using the DNA molecules inside the living tissue, this type of computation is applied in many application areas such as me...

A microfluidic approach has been developed for the real-time detection of drug effects, based on the quantitative measurement of calibrated cytosolic calcium ([Ca(2+)](i)) on single cancer cells. This microfluidic method is rapid by detecting the early event of cytotoxicity of drug candidates on cancer cells, without waiting for a couple of days needed for cell seeding and drug treatment by con...

A microfluidic-based biochip made of poly-(dimethylsiloxane) was recently reported for the first time by us for the incubation of precision-cut liver slices (PCLS). In this system, PCLS are continuously exposed to flow, to keep the incubation environment stable over time. Slice behavior in the biochip was compared with that of slices incubated in well plates, and verified for 24 h. The goal of ...

In this paper we report a microfluidic model to simulate the bronchi of a cystic fibrosis (CF) patient. The biochip is comprised of two cell culture chambers separated by a membrane. On top of the membrane an alginate hydrogel is formed in order to simulate the thick mucus layer spotted in a CF bronchi. In the bottom chamber a monolayer of epithelial cells are cultured to simulate the bronchi t...

Microfluidic biochips are becoming more and more popular in biomedical laboratory and also industry. Different from the continuous-flow microfluidic systems, a new generation of microfluidic biochips, referred to as digital microfluidic chips, has evolved over time and it offers advantages such as on-line reconfiguration and fault-tolerant operation. The principles behind the digital microfluid...