Nifedipine, prenylamine and verapamil are coronary vasodilators the mechanism of action of which is attributed mainly to calcium antagonism (1, 2). Pronounced negative inotropic effects of these drugs were reported for prenylamine by Linder (3), for verapamil by Haas et al. (4), and for nifedipine by Vater et al. (5), Hashimoto et al. (6), and Flecken stein et al. (1, 2). A coronary vasodilator...

Objective: The purpose of this study was to determine the optimum formula diltiazem HCl-loaded chitosan nanoparticles due variations in speed and duration stirring evaluating release kinetics vitro using DDSolver.
 Methods: method used prepare is ionic gelation. gelation involves an cross-linking between cations on backbone anion, such as sodium tripolyphosphate (Na TPP). 
 Results: S...

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