dipeptidyl peptidase 4

Akihiko Sato Akiomi Yoshihisa Yuki Kanno Mai Takiguchi Shunsuke Miura Takeshi Shimizu Yuichi Nakamura Hiroyuki Yamauchi Takashi Owada Takamasa Sato Satoshi Suzuki Masayoshi Oikawa Takayoshi Yamaki Koichi Sugimoto Hiroyuki Kunii Kazuhiko Nakazato Hitoshi Suzuki Shu‐ichi Saitoh Yasuchika Takeishi

BACKGROUND Heart failure (HF) and diabetes mellitus (DM) often co-exist. Treatment of DM in HF patients is challenging because some therapies for DM are contraindicated in HF. Although previous experimental studies have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors improve cardiovascular function, whether DPP-4 inhibition improves mortality of HF patients with DM remains unclear. Ther...

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DPP-4 Inhibitor-Induced Rheumatoid Arthritis Among Diabetics: A Nested Case–Control Study

2018

Niranjan Kathe Anuj Shah Qayyim Said Jacob T. Painter

INTRODUCTION The risk of rheumatoid arthritis (RA) associated with dipeptidyl peptidase-4 inhibitor (DPP-4i) use is unclear. This study assesses the RA risk associated with DPP-4i use among a diabetic cohort initiating second-line therapy. METHODS This was a nested case-control study, using the adult diabetic population starting second-line antidiabetic therapy from IMS LifeLink Plus® databas...

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Treatment progression in sulfonylurea and dipeptidyl peptidase-4 inhibitor cohorts of type 2 diabetes patients on metformin

2016

Xiaomei Peng Dingfeng Jiang Dongju Liu Oralee J Varnado Jay P Bae

BACKGROUND Metformin is an oral antidiabetic drug (OAD) widely used as first-line therapy in type 2 diabetes (T2D) treatments. Numerous treatment pathways after metformin failure exist. It is important to understand how treatment choices influence subsequent therapy progressions. This retrospective study compares adherence to, persistence with, and treatment progression in sulfonylurea (SU) and...

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