Approximately 53% of the protein sequences in the National Biomedical Research Foundation (NBRF) database can be allocated to one of 26 functional classes, each of which can be characterized by the joint occurrence of four or fewer attributes. The attributes reflect collective physicochemical properties of the sequences in a class, ranging from simple characteristics of composition, such as ave...

Data are the foundation of empirical research, yet all too often the datasets underlying published papers are unavailable, incorrect, or poorly curated. This is a serious issue, because future researchers are then unable to validate published results or reuse data to explore new ideas and hypotheses. Even if data files are securely stored and accessible, they must also be accompanied by accurat...

Rapid progress in multiple genome projects continues to feed databases in the world a large volume of sequence data. In this 'post-genomic' era, more efficient and reliable sequence annotation, especially functional annotation of protein sequences, is crucial. Although experimental confirmation is ultimately required, computational annotation of protein sequences has been routinely done, and it...

background: female sexual dysfunction (fsd) is a real problem that affects 25-63% of women. there is no valid persian version of sexual function questionnaire (fsq). objectives: the aim of this study was to test the reliability and validity of persian version of sexual function questionnaire. materials and methods: in this cross-sectional study, 547 women were questioned by persian version of s...

background nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. in this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (pds) in cisplatin-induced nephrotoxicity. method a total of 207 normal and toxic rats’ kidney tissue (induced b...

The ability to predict organ-specific carcinogenicity would aid FDA reviewers in evaluating new chemical applications. A NCTR liver cancer database (NCTRlcdb) containing 999 compounds has been developed with three sets of descriptors. The NCTRlcdb has Cerius2, Molconn-Z, and (13)C NMR descriptors for each compound. Each compound in the database was assigned a liver cancer or a nonliver cancer c...

Different thyroid function tests permitted a final classification of 204 consecutive patients with suspected thyroid disorders into three populations (thyrotoxic, euthyroid, and hypothyroid). Linear discriminant analysis was applied to all test results (10 variates) on adjacent population pairs. Two invitro tests (serum protein bound iodine (P.B.I.) and tri-iodothyronine (T-3) uptake values) ga...

The classification problem is an important topic in knowledge discovery and machine learning. Traditional classification tree methods and their improvements have been discussed widely. This work proposes a new approach to construct decision trees based on discriminant functions which are learned using genetic programming. A discriminant function is a mathematical function for classifying data i...

Discriminant analysis is a technique for the multivariate study of group differences. More specifically, it provides a method of examining the extent to which multiple predictor variables are related to a categorical criterion, that is, group membership. Situations in which the technique is particularly useful include those in which the researcher wishes to assess which of a number of continuou...