The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron HCl using a direct compression method. A combination of glycine and chitosan was used as a disintegrating system and these tablets were compared for mechanical strength and disintegration time with those containing superdisintegrants. The Plackett-Burman screening design was used to screen the indepe...

We show that the existence of disintegration for cylindrical measures follows from a general disintegration theorem for countably additive measures.

Disintegration by hydrodynamic cavitation has a positive effect on the degree and rate of sludge anaerobic digestion. By applying hydrodynamic disintegration the lysis of cells occurs in minutes instead of days. The intracellular and extracellular components are set free and are immediately available for biological degradation which leads to an improvement of the subsequent anaerobic process. H...

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration ...

Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...