In this communication, we develop a simple pathway to prepare SERS-active substrates with Au nanoparticles (NPs) by an electrochemical strategy of deposition-dissolution cycles (DDCs). The prepared SERS-active substrates demonstrate large Raman scattering enhancement for Rhodamine 6G (R6G) with a detection limit of 2 × 10(-12) M and an enhancement factor of 5.8 × 10(7).

BCS class II drugs pose challenging problems in their pharmaceutical product development process because of their low solubility and dissolution rates. They require enhancement in solubility and dissolution rate in their formulation development especially solid dosage forms such as tablets and capsules. Several conventional methods and new emerging technologies have been developed for formulati...

Enzalutamide (ENZ) is a BCS class II, fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Ternary solid dispersion of was prepared with water-soluble polymers Soluplus (SOL) and Poloxamer P 188 (POL) by solvent evaporation spray drying technique. Initially, different ratios Soluplus: solvents were used to prepare dispersions evaluated for the dissolution enh...