Drug dissolution studies are commonly conducted using compendial methods employing USP Paddle and Basket apparatuses. In many cases, dissolution studies can be of limited benefit especially for product-dependent dissolution procedures like in extended release (ER) formulations. The high variability in dissolution testing, that is not productrelated, emphasizes the need for developing new method...

in this study, the effect of recrystallization of naproxen in the presence of hydroxypropyl cellulose (hpc) on the release rate of drug was investigated. crystals were generated by the anti-solvent approach using the hpc solution in water as the anti-solvent. the samples were subjected to various physicochemical evaluations such as crystal size, scanning electron microscopy, fourier transform i...

ezetimide belongs to a class of lipid lowering compounds that selectively inhibits intestinal absorption of cholesterol and related phytosterols. the purpose of this study is to establish a reliable and quick method for the assignment of ezetimibe in tablets form by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sensitive hplc method has been developed ...

tolterodine tartrate, is a new, potent and competitive muscarinic receptor antagonist in clinical development for the treatment of urge incontinence and other symptoms of unstable bladder. the purpose of this study is to establish a reliable and quick method for the assignment of tolterodine tartrate by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sen...

the dried fruit of terminalia chebula is widely used for its laxative properties. the objective of the present study was to examine the flowability and compressibility of terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. initial studies on flowability and compressibility revealed that the fruit powder...

objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...

calcium acetate is used as an oral phosphate binder to control hyperphosphatemia in patients with chronic renal failure. compared to calcium carbonate, control of hyperphosphatemia can be achieved at lower calcium administration with calcium acetate which likely reduces the risk of hypercalcemia. in this study, various formulations of calcium acetate tablets were prepared and their disintegrati...

The corrosion behaviour of a non-equiatomic CoCrFeNiMo high-entropy alloy (HEA) in H2S-containing and H2S-free environments was studied by electrochemical tests, surface characterization, solution analysis. results showed that the HEA exhibited primary secondary passivation environment, transition owing to enhanced dissolution Fe species. Compared with passive film, Cr/Fe ratio film increased a...

The orally disintegrating tablet (ODT) is a novel dosage form that disintegrates in the oral cavity using saliva as the disintegrating medium and is swallowed as a fine dispersion. Due to rapid disintegration, the dissolution rate is controlled by the intrinsic solubility of the API; therefore, it is difficult to evaluate the effect of formulation and processing parameters on in vitro drug rele...

meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...