The intent of this work was to study the effect of polymorphism on dissolution properties and to apply several methods to evaluate the dissolution profiles of immediate-release tablets containing alpha (α) and beta (β) forms of eletriptan hydrobromide (EH). The polymorphs were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and diffuse reflectance infrared Fou...

A quantitative understanding of the mechanism of human dental enamel dissolution in buffers is important because it should lead to a clear description of the causative factors in caries formation, and it can be profitably employed in the design of meaningful screening methods for potential anti-decay agents. Gray' has reported studies on enamel dissolution, concluding that the rates of dissolut...

In recent years, great progress has been made in the dissolution of cellulose with ionic liquids (ILs). However, the mechanism of cellulose dissolution, especially the role the IL cation played in the dissolution process, has not been clearly understood. Herein, the mixtures of cellulose with a series of imidazolium-based chloride ionic liquids and 1-butyl-3-methyl pyridinium chloride ([C(4)mpy...

Standard compendia dissolution apparatus are the first choice for development of new dissolution methods. Nevertheless, limitations coming from the amount of material available, analytical sensitivity, lack of discrimination or biorelevance may warrant the use of non compendial methods. In this regard, the use of small volume dissolution methods offers strong advantages. The present study aims ...

Using two complimentary approaches (pore water advection/diffusion/ reaction modeling and stable isotope mass balance calculations) we show that carbonate dissolution/reprecipitation occurs on early diagenetic time scales across a broad range of sediments on the Great Bahamas Bank. The input of oxygen into the sediments, which strongly controls sediment carbonate dissolution, has two major sour...

This study explored the application of 400-DS dissolution apparatus 7 for individual pellet dissolution methodology by a design of experiment approach and compared its capability with that of the USP dissolution apparatus 1 and 2 for differentiating the coat quality of sustained release pellets. Drug loaded pellets were prepared by extrusion-spheronization from powder blends comprising 50%, w/w...

Solid dispersion systems are widely investigated for the dissolution enhancement of poorly water soluble drugs. Nevertheless, very limited commercial use has been achieved due to the poor predictability of such systems caused by the lack of a basic understanding of the dissolution optimization mechanism. In the present study an investigation of the release mechanism is performed for solid dispe...

I discuss the possibility that the quark-gluon plasma at strong coupling admits a description in terms of a black hole in asymptotically anti-de Sitter space. Prepared for the Proceedings of Recent Developments in Gravity – NEB XIII, Thessaloniki, Greece, June 2008. Research supported in part by the US Department of Energy under grant DE-FG05-91ER40627. E-mail: [email protected]

Dissolution testing measures the rate of drug substance release into solution, impacting the extent of drug absorption. Drug manufacturers and regulatory agencies use dissolution testing to identify drug products that do not meet the desired clinical performance. Formulation composition and manufacturing processes can impact the material attributes of a drug product, which directly affect the d...

The anodic dissolution of 100Cr6 steel in neutral electrolytes containing sodium chloride and sodium nitrate was investigated potentiodynamically and galvanodynamically with a rotating disc electrode at room temperature. The total concentration of the mixed electrolyte was 3 mol L with variation of chloride/nitrate mole ratios. The potentiodynamic linear sweep voltammograms (LSVs) in mixed elec...