OBJECTIVE We investigated the comparative roles of mitogen-activated protein (MAP) kinases, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38, in vascular smooth muscle cell (VSMC) proliferation, migration, and gene expression. METHODS AND RESULTS VSMCs were infected with recombinant adenovirus containing dominant-negative mutants of ERK, p38, and...

We consider presentations that were derived in [3] for the interval groups associated with proper quasi-Coxeter elements of Coxeter group W(Dn). use combinatorial methods to derive alternative groups, and these new show a element W(Dn) cannot be isomorphic Artin type Dn. While specific problems we solve arise from study their solution provides an illustration how techniques indicated by computa...

14-3-3 family members are dimeric phosphoserine-binding proteins that regulate signal transduction, apoptotic, and checkpoint control pathways. Targeted expression of dominant-negative 14-3-3eta (DN-14-3-3) to murine postnatal cardiac tissue potentiates Ask1, c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activation. DN-14-3-3 mice are unable to compensate for pr...

Diabetic nephropathy (DN) is one of the most serious chronic microvascular abnormalities diabetes mellitus and major cause uremia. Accumulating evidence has confirmed that fibrosis a significant pathological feature contributes to development kidney disease in DN. However, exact mechanism renal DN still unclear, which greatly hinders treatment Chinese herbal medicine (CHM) shown efficacy safety...

BACKGROUND Diabetic neuropathy (DN) is a common complication of diabetes that has significant economic burden, especially for patients with comorbid depression or anxiety. This study examines and quantifies factors associated with healthcare costs among patients diagnosed with diabetic neuropathy (DN) with or without a comorbid diagnosis of depression or anxiety (DA) using retrospective adminis...

BACKGROUND Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. MATERIALS AND METHODS We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and...

Anticorrelation between the default network (DN) and dorsal attention network (DAN) is thought to be an intrinsic aspect of functional brain organization reflecting competing functions. However, the effect size of functional connectivity (FC) between the DN and DAN has yet to be established. Furthermore, the stability of anticorrelations across distinct DN subsystems, different contexts, and ti...