Introduction: tegrity is the most important component for transferring genetic information Sperm DNA fragmentation is considered a component of male infertility. Its assessment comprises conventional semen analysis of which emphasis is placed on its evaluation in fertility clinics. In this study, we investigate the relationship between sperm parameters of motility, morphology, concentratio...

Background: It is stated that pentoxifyline can improve sperm motility and suggested to use in ART for asthenozoospermia. But, probable effect of this drug on sperm DNA in unknown. Our main goal was to evaluate the impact of pentoxifyline on sperm DNA fragmentation. Materials and Methods: Thirty eight asthenozoospermic patients were selected for this prospective study. After direct swim-up, spe...

The assessment of the indicators reproductive potential male white rats exposed to smoke for 1 month was carried out. Examination animals included determination spermatogenesis index and level DNA fragmentation methylation in testes blood. A statistically signifi-cant increase genome-wide blood revealed. morphometric study testis tissue revealed a violation indices rats.

We evaluated the effect of varicocelectomy on semen parameters and levels of sperm DNA damage in infertile men. A total of 75 infertile men with varicocele and 40 fertile men (controls) were included in this study. Semen analysis and sperm DNA damage expressed as the DNA fragmentation index using acridine orange staining and chromatin condensation test by flow cytometry were assessed before and...

OBJECTIVE To evaluate the effect of vaginal lubricants Pre-Seed, FemGlide, Astroglide, and Replens on human sperm motility and chromatin integrity. DESIGN Prospective, comparative, in vitro study. SETTING Andrology laboratory at tertiary care hospital. PATIENT(S) Thirteen normozoospermic donors. INTERVENTION(S) Semen samples from 13 subjects were incubated in human tubal fluid media (HT...

INTRODUCTION Although the pathophysiology of the testicular damage associated with varicocele remains unclear, sperm DNA damage has been identified as a potential explanation for this cause of male infertility. The current study was designed to determine the extent of sperm nuclear DNA damage in patients with varicocele, and to examine its relationship with parameters of seminal motility. MAT...

Background: Although sperm selection according to morphologic and motility characteristic, made to some what the fertility successful, but sperm’s normal morphology cannot demonstrate sperm DNA competence. Since the health of sperm DNA is affecting the results of assisted reproductive technology; the aim of this study is to evaluate semen parameters measured by CASA with sperm chromatin abnorma...