Effect of ration level and dietary docosahexaenoic acid content on the requirements for long-chain polyunsaturated fatty acids by juvenile barramundi (Lates calcarifer), Aquaculture, 433, pp. 164-172. 1 Title: Effect of ration level and dietary eicosapentaenoic acid content on the requirements for docosahexaenoic acid by juvenile barramundi (Lates calcarifer). Abstract 27 Juvenile barramundi we...

BACKGROUND Despite the significant amount of work being carried out to investigate the therapeutic potential of docosahexaenoic acid (DHA) in Alzheimer's disease (AD), the mechanism by which DHA affects amyloid-β precursor protein (AβPP)-induced metabolic changes has not been studied. OBJECTIVE To elucidate the metabolic phenotypes (metabotypes) associated with DHA therapy via metabonomic pro...

Neuroprostanes are lipid mediators produced by nonenzymatic free radical peroxidation of docosahexaenoic acid (DHA). DHA is associated with a lower atherosclerosis risk, suggesting a beneficial role in cardiovascular diseases. The aim of this study was to investigate the influence of DHA peroxidation on its potentially antiarrhythmic properties (AAP) in isolated ventricular cardiomyocytes and i...

The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to promote recovery of motor function after spinal cord injury. This is likely to be at least partly due to neuroprotective effects of DHA. However, recent studies have shown that DHA also supports neuroplasticity after injury, such as promoting sprouting of spared corticospinal tract (CST) axons. In this chapter...

Seasonal variations of proximate compositions and fatty acids of tench (Tinca tinca) captured from Seyhan Dam Lake were investigated. The results showed that seasonal fatty acid compositions of tench fillets in July, August and November ranged from 29.59% to 33.71% for saturated fatty acids (SFA), from 20.50% to 21.69% for monounsaturated fatty acids (MUFAs) and from 26.50% to 41.85% for polyun...

Infant formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA) are now available in the United States; however, little is known about the factors that affect biosynthesis. Baboon neonates were assigned to one of four treatments: term, breast-fed; term, formula-fed; preterm (155 of 182 days gestation), formula-fed; and preterm, formula+DHA/ARA-fed. Standard formula had n...

Docosahexaenoic acid (DHA, 22:6 n-3) is an omega-3 fatty acid with a 22 carbon acyl chain containing six cis double bonds and is predominantly found in membrane glycerophospholipids. Dietary consumption of DHA has been positively linked with the prevention of numerous pathologies and consequently, it has been the focus of extensive research over the last four decades. Nevertheless, our understa...

OBJECTIVE To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. METHODS Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spati...

OBJECTIVE Docosahexaenoic acid (DHA) might help prevent or attenuate posttraumatic stress disorder (PTSD) symptoms. We examined the efficacy and safety of DHA for preventing PTSD (DSM-IV) after severe accidental injury. METHOD From December 2008 to August 2013, we conducted a randomized, double-blind, placebo-controlled trial of 110 accident-injured patients consecutively admitted to an inten...

The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in the brain. Decreased DHA in the developing brain leads to deficits in neurogen...