This Task Force document explores the ethical issues involved in the debate about the scope of genetic screening of gamete donors. Calls for expanded donor screening arise against the background of both occasional findings of serious but rare genetic conditions in donors or donor offspring that were not detected through present screening procedures and the advent of new genomic technologies pro...

introduction: cytomegalovirus (cytome-galovirus: cmv) infection is a common cause of morbidity and mortality in patients who are the candidate for liver transplant. serological monitoring of individuals rece-iving and giving the liver transplant is necessary for prevention, early diagnosis and treatment strategies and reducing the prevalence of infection. the aim of this study was to assess the...

BACKGROUND To resolve the current shortage of donor hearts, we established the Adonhers protocol. An upward shift of the donor age cut-off limit (from the present 55 to 65 years) is acceptable if a stress echo screening on the candidate donor heart is normal. This study aimed to verify feasibility of a "second opinion" of digitally transferred images of stress echo results to minimize technical...

Transplantation is the preferred treatment for the most serious forms of kidney disease; deceaseddonor and live-donor kidneys are the two sources for transplantation, and these sources are utilized via two different programs. One of these programs, a two-way kidney paired donation (KPD), involves two patient-donor couples, for each of whom transplantation from donor to intended recipient is not...

PURPOSE To identify the genetic cause of isolated canine ectopia lentis, a well-characterized veterinary disease commonly referred to as primary lens luxation (PLL) and to compare the canine disease with a newly described human Weill-Marchesani syndrome (WMS)-like disease of similar genetic etiology. METHODS Genomewide association analysis and fine mapping by homozygosity were used to identif...

BACKGROUND AND OBJECTIVES ESRD has an adverse impact on patients who have had previous nonrenal solid-organ transplants (NRTxs; liver, heart, lung) and may be referred for a kidney transplant (KTx). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Using Scientific Registry of Transplant Recipients data for all KTx candidates who had NRTx and were listed between 1995 and 2008, incidence of NRTx l...

The aim of this study was to investigate the normal values of glomerular filtration rate (GFR) by technetium-99m diaethylene-triamine-pentaacetic acid ((99m)Tc-DTPA) renal dynamic imaging for living kidney graft donors. In a total of 212 candidate donors, GFR was examined using (99m)Tc-DTPA renal dynamic imaging. Donors with GFR≥80mL/(min×1.73m(2)) and as low as with GFR≥70mL/(min×1.73m(2)) but...

*(Unfeasible is defined as autograft is no longer available because of prior use or insufficient tissue or the candidate is unacceptable because of any of the following reasons obesity, over 65 years of age, morbidity preventing harvesting at autograft donor site (infection, fracture), excessive risk of anatomic disruption from harvesting, osteoporosis, concurrent medical conditions and co-morb...

We report the presence, in heavily doped and compensated ZnSe:N, of a resonant donor defect having an activation energy of .120– 160 meV. The donor-acceptor pair photoluminescence observed in these materials is quenched at pressures higher than 25 kbar. We attribute this quenching to the shift of a resonant defect level into the band gap. A split N-N interstitial on a Se site is proposed as a s...

the fabrication of a non-doped red organic light-emitting device (oled) has been developed using naturally occurring curcumin as an emissive layer of oled. in this research, the electroluminescent spectrum (el) of curcumin as a donor-acceptor-donor (d-a-d) chromophore was obtained at wavelength of 612 nm. also, the maximum external quantum efficiencies (eqe) for this device was measured and fou...