OBJECTIVE To compare the outcomes of protocols for ovarian stimulation with recombinant hCG microdose, with GnRH agonists and antagonists for pituitary suppression. DESIGN Prospective nonrandomized clinical trial. SETTING A private assisted reproduction center. PATIENT(S) We studied 182 patients undergoing intracytoplasmic sperm injection (ICSI) cycles, allocated into two groups: GnRH ago...

The placenta may be involved in the regulation of the maternal thyroid function during pregnancy. As human chorionic gonadotropin (hCG) is a primary protein from the placenta, we examined the thyrotropic activity of hCG and its derivatives using tissue culture and monolayer cell culture of human thyroid glands. The TSH receptor preparation was made from thyroid tissues, and its binding affinity...

OBJECTIVE To evaluate the effect of low levels of endogenous luteinizing hormone (LH) and low-dose human chorionic gonadotropin (hCG) supplementation on in vitro fertilization (IVF) cycle outcomes in a gonadotropin-releasing hormone (GnRH) antagonist protocol. DESIGN Retrospective study. SETTING Military medical center. PATIENT(S) General in vitro fertilization/embryo transfer (IVF-ET) po...

background: nowadays, the first step in treatment of ectopic pregnancy (ep) is medical treatment. medical treatment with methotrexate (mtx) for ep is safe and effective method without the risks associated with the surgical procedure. but there are controversies between studies for which patients will respond better to medical treatment. objective: the aim of the present study was to investigate...

Previous investigations of patients with gestational trophoblastic neoplasia have shown that their urines often contain carboxyterminal peptide (CTP) fragments of the choriogonadotropin (hCG) beta-subunit as well as forms of hCG deficient in sialic acid. In order to determine whether beta-CTP fragments are among the urinary products of the peripheral degradation of desialylated hCG (as-hCG), us...

Ovarian hyperstimulation syndrome (OHSS) is one of the major complications in artificial reproductive technology, especially in high responders. Exogenous human chorionic gonadotropin (hCG) for triggering final oocyte maturation during controlled ovarian stimulation (COS) is primarily responsible for the pathogenesis of early-onset OHSS. Several strategies were offered to prevent OHSS, includin...

Hormone-induced regulation of luteinizing hormone (LH) receptors and desensitization of target cell responses were studied in purified Leydig cells prepared from testicular interstitial tissue of rats treated with 0.2, 1, and 10 pg of human chorionic gonadotropin (hCG). The extent and rate of LH receptor loss after hCG were dose-related, with maximum decreases of 50, 80, and 95% at 4, 2, and 1 ...

BACKGROUND Nowadays, The first step in treatment of ectopic pregnancy (EP) is medical treatment. Medical treatment with methotrexate (MTX) for EP is safe and effective method without the risks associated with the surgical procedure. But there are controversies between studies for which patients will respond better to medical treatment. OBJECTIVE The aim of the present study was to investigate...

AIM Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy. Another glycoprotein, glycodelin A, is one of the main products of the maternal decidua during this period. The purpose of this study was to investigate the effect of glycodelin A on hCG release by isolated cytotrophoblast cells in vitr...

OBJECTIVE To examine whether in smokers there is a significant dose dependency between the number of cigarettes per day and levels of free ss-hCG and pregnancy-associated plasma protein A (PAPP-A) at 11-13(+6) weeks of gestation. METHODS This was a retrospective analysis of the maternal serum free ss-hCG and PAPP-A levels in relation to the maternal smoking status in 109 263 chromosomally nor...