A patient failed to wean from mechanical ventilation. Her problem was unique in that she had a depressed central drive to breathe manifested by hypopnea when removed from the ventilator. After excluding the known problems that impair successful weaning, we empirically administered three separate infusions of doxapram, a respiratory stimulant. These infusions produced a dramatic improvement in s...

The goal of this study was to determine when fetal breathing movements (FBMs) commence in the rat and to characterize age-dependent changes of FBMs in utero. These data provide a frame of reference for parallel in vitro studies of the cellular, synaptic, and network properties of the perinatal rat respiratory system. Ultrasound recordings were made from unanesthetized Sprague-Dawley rats from e...

Dysregulation within both respiratory control systems and the hypothalamic-pituitary adrenal (HPA) axis has been implicated in the pathophysiological of panic disorder. However, potential linkages between respiration and the HPA axis have rarely been examined in panic patients. We have previously published neuroendocrine and psychophysiological response data from a laboratory panic model using ...

Ellis BW. Symptomatic treatment of primary pneumatosis coli with metronidazole. Br Med J 1980 ;280 :763-4. 2 Down RHL, Castleden WM. Oxygen therapy for pneumatosis coli. Br MedJ3 1975;i:493-4. Andersen JB, Olesen KP, Eikard B, Janser E, Qvist J. Periodic continuous positive airway pressure, CPAP, by mask in the treatment of atelectasis. EurJ_ Respir Dis 1980;61:20-5. Edwards G, Leszczynski SO. ...