نتایج جستجو برای: doxorubicin dr

تعداد نتایج: 108951  

Journal: :acta medica iranica 0
ahmadiasl n mohammadi naghadeh m rostami a

we investigated the vasodilatory effect of isoprenaline at large vessels (aorta, renal ans saphenous arteries, vena cava, renal and saphenous veins) in doxorbicin-induced model of heart failure. thirty saline-treated (normal group) and thirty doxorubicin treated rabbits (1 mg/kg administered intravenously twice weekly for 8 weeks) were studied after 16 weeks of treatment. chronic heart failure ...

ژورنال: دانشور پزشکی 2018
حقیرالسادات, بی بی فاطمه, زندیه دولابی, بهروز, عموعابدینی, قاسم, منتظری, فاطمه, نادری نژاد, سمیرا,

Background and Objective: In the present study, PEGylated liposomal formulation containing doxorubicin was synthesized in order to study the effects of surface charge on its cytotoxicity.   Materials and Methods: Liposomal doxorubicin containing DPPC, cholesterol and phospholipid DSPE-mPEG with various amounts of cationic phospholipid, DOTAP, (0, 5.2 and 20%) was prepared by pH gradient ...

Journal: :Gastroenterology & hepatology 2015
Gary R Lichtenstein

most frequently asked questions is what they should eat. Ms Karina Knight-Sepulveda, Dr Susan Kais, Dr Rebeca Santaolalla, and Dr Maria T. Abreu explore diets commonly recommended to IBD patients—such as the low–fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet; the specific carbohydrate diet; the anti-inflammatory diet; and the Paleolithic diet—and review the data curr...

Journal: :iranian journal of basic medical sciences 0
leila hosseinzadeh medical toxicology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran javad behravan biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran fatemeh mosaffa biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran gholamreza bahrami medical biology research center, kermanshah university of medical sciences, kermanshah, iran ahmad reza bahrami faculty of sciences, ferdowsi university of mashhad, mashhad, iran gholamreza karimi medical toxicology research centre, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) doxorubicin (dox), a widely used chemotherapeutic agent can give rise to serve cardiotoxicity by inducing apoptosis. curcumin, the active compound of the rhizome of curcuma longa l. has anti-inflammatory, antioxidant and anti-proliferative activities. curcumin has been identified to increase cytotoxicity in several cancer cell lines in combination with dox, but there is no study ab...

2016
JIE TANG HONGXUAN ZHOU CHUN WANG XIAODONG FEI LIqUN ZHU YUEJIAO HUANG YUNHUA HE JING LIU XIAOBING MIAO YAXUN WU YUCHAN WANG

Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma (MM). We found that Homer1b/c was lowly expressed in MM cell apoptotic model induced by doxorubicin. The positive role of Homer1b/c in c...

حسینی, آذر, رخشنده, حسن, مهدیان, داوود,

Background and Objective: Doxorubicin is one of the most effective chemotherapeutic agents against solid tumors. Doxorubicin causes cardio-toxicity via production of free radicals and depletion of anti-oxidants. However, the use of anti-oxidants can decrease doxorubicin-induced cardio-toxicity. Apium graveolens (celery) contains anti-oxidant compounds. Hence, this study was an attempt to figure...

Attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) and doxorubicin. Biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. PLGA nanoparticles were formulated by sonication method. Lactide/glycolide ratio ...

Journal: :journal of chemical health risks 0
jamshid l. manzoori department of chemistry, faculty of science, tabriz branch, islamic azad university, tabriz, iran jafar abulhassani department of chemistry, faculty of science, tabriz branch, islamic azad university, tabriz, iran navid niaei department of chemistry, faculty of science, tabriz branch, islamic azad university, tabriz, iran

.a simple spectrofluorimetric method is described for the determination of doxorubicin (dxr) based on its quenching effect on the fluorescence intensity of tb 3+ - deferasirox (dfx) complex as a fluorescent probe. the excitation and emission wavelengths were 328 and 545 nm, respectively. the effects of ph, time, order of addition of reagents, concentrations of tb 3+ and dfx and the buffer volum...

Journal: :Journal of Molecular Liquids 2022

Doxorubicin is cytotoxic anthracycline antibiotic drug used in cancer treatment. The drug’s efficacy various kinds of made its usage dominant for treating cancers. In this study, we determined the solubility doxorubicin three different polymers, i.e., poly (N-isopropyl acrylamide), polyethylene glycol, and polyvinyl pyrrolidone, to increase doxorubicin’s on targeted tumor site. We investigated ...

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