نتایج جستجو برای: dr1 transgenic mice
تعداد نتایج: 423333 فیلتر نتایج به سال:
Background: Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons resulting in muscle atrophy. In contrast to the lower neurons, role upper (cortical) ALS yet unclear. Maturation locomotor networks supported dopaminergic (DA) projections from substantia nigra spinal cord and striatum. Objective: To examine contribution DA mediation striatum-cortex progression. Me...
We analyzed the binding of an influenza matrix protein-derived peptide, MAT(17-31), to cell surface and purified DR1. The pH dependence of peptide binding was dramatically influenced by the membrane environment. Cell surface binding was enhanced at low pH, with little or no binding detected at neutral pH and optimal binding at pH 4. By contrast, hydrogen ion concentration had minimal effect on ...
فرایند UV/H2O2 در رنگبری پساب کارخانههای نساجی استفاده شده است. در این پژوهش، رنگبری دو رنگینه پراکنده یکی با ساختار آزو (Red1, DR1) و دیگری با ساختار آنتراکینون (Blue56, DB56) با استفاده از فرایند اکسایش UV/H2O2 بررسی شد. برای به دست آوردن شرایط عملکرد بهینه و مؤثر در این روش اثر عوامل مؤثر شامل غلظت هیدروژن پراکسید، غلظت رنگزا، pH و نیز مقدار فا...
abstract background: determination of transgenic embryos from non transgenic embryos sibling is an important step in producing homozygous transgenic mice. these steps need by pcr or southern blotting followed extraction of dna, but both techniques require skill and consume time. objective: the aim of this study was simulation of high accuracy method using novel enhanced green fluorescent protei...
BACKGROUND There are several reports demonstrating the role of CD8 T cells against Leishmania species. Therefore peptide vaccine might represent an effective approach to control the infection. We developed a rational polytope-DNA construct encoding immunogenic HLA-A2 restricted peptides and validated the processing and presentation of encoded epitopes in a preclinical mouse model humanized for ...
Mice reconstituted with a human immune system provide a tractable in vivo model to assess human immune cell function. To date, reconstitution of murine strains with human hematopoietic stem cells (HSCs) from patients with monogenic immune disorders have not been reported. One obstacle precluding the development of immune-disease specific "humanized" mice is that optimal adaptive immune response...
A putative RNA-binding protein positively regulates salicylic acid-mediated immunity in Arabidopsis.
RNA-binding proteins (RBP) can control gene expression at both transcriptional and post-transcriptional levels. Plants respond to pathogen infection with rapid reprogramming of gene expression. However, little is known about how plant RBP function in plant immunity. Here, we describe the involvement of an RBP, Arabidopsis thaliana RNA-binding protein-defense related 1 (AtRBP-DR1; At4g03110), in...
An increased omega-3 polyunsaturated fatty acid (n-3 PUFA) tissue status can lead to a significant formation of anti-inflammatory lipid mediators and effective reduction in inflammation injury murine colitis. Arachidonic lipoxygenases (ALOX) have been implicated the pathogenesis inflammatory bowel disease as well pro- mediators. To explore role Alox15 protective response found fat1 transgenic m...
Efficient production of transgenic animals using low-titer lentiviral constructs remains challenging. Here we demonstrate that microinjection of simian immundeficiency virus-derived lentiviral constructs can produce transgenic mice and rats with high efficiency even when using low-titer virus preparations.
The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been extensively used for placenta-specific gene inactivation. In a pilot study, we observed unexpected phenotypes using this strain, which prompted an extensive characterization of Cyp19-Cre placental ROSAmT/mG reporter mice. two strains were mated to generate bi-transgenic Cyp19-Cre;ROSAmT/mG mice following standard breeding...
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