Background and objectives: Dorema ammoniacum gum resin is used in Iranian traditional medicine for different indications including inflammatory diseases which are on the rise. Considering the important role of inflammation in different diseases, in the present study, we aimed to investigate the in vivo anti-inflammatory activity and skin toxicity of Dorema ammoniac...

In this work, a peptide for ocular delivery (POD) and human immunodeficiency virus transactivator were conjugated with biodegradable poly(lactic-co-glycolic acid) (PGLA)-polyethylene glycol (PEG)-nanoparticles (NPs) in an attempt to improve ocular drug bioavailability. The NPs were prepared by the solvent displacement method following two different pathways. One involved preparation of PLGA NPs...

This study investigated the suspension of poly(ε-caprolactone) nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs) in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.5%) and submitted individually for freeze-drying a...

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

The aim of this study was to assess the irritant properties of a new developed calcium phosphate ceramic, α-tricalcium phosphate (α-TCP) after single application to intact skin of the rabbit. The test substance, α-TCP was produced by modified hydrothermal method and prepared in two different forms, as a solid material (disc 5 × 2 mm) and paste. Both, solid material and paste of α-TCP were evalu...

Background The aim of the study was to develop a sustained ocular delivery of brinzolamide (BLZ) based on gellan gum. Methods The formulations were characterized for clarity, gelling capacity, rheological studies, pH, drug content, and in vitro drug-release behavior. In vivo rabbit eye irritation test was conducted to evaluate irritation of the BLZ gel drug-delivery system. The prepared BLZ f...

Abstract This research aimed to prepare and characterize a new type of polymeric cross-linked topical hydrogel patches for the treatment wound infections. The free radical polymerization method was used by utilizing natural polymers, i.e., agarose gelatin. These polymers were chemically with monomer (acrylic acid) using ammonium persulfate as an initiator via cross-linker N , methylene bisacryl...

Propylene glycol phenyl ether exhibits low acute toxicity by the oral, and inhalation routes. The oral LD50 in rats exceeds 2000 mg/kg (1 death from 10 subjects occurred at this highest dose tested); and the 4-hour inhalation LC50 in rats was greater than 5400 mg/m (no deaths). PPh was severely irritating to the eyes but non-irritating to skin in rabbits tested and evaluated according to the Dr...

Replacement of the rabbit Draize skin irritation test or the animal photo-irritation test is in course in Europe under the REACH chemical strategy and the Cosmetics Directive. Various in vitro protocols, including 3D skin models, have been assessed. One key difficulty in determining the validity of alternative in vitro methods is that the in vivo animal data is both scarce and often of limited ...