Objective: Effective utilization of an optical tracking system for image-based surgical guidance requires optimal placement of the dynamic reference frame (DRF) with respect to the tracking camera. Unlike other studies that measure the overall accuracy of a particular navigation system, this study investigates the precision of one component of the navigation system: the optical tracking system ...

The biogenic amine serotonin is a signaling molecule in the gastrointestinal tract, platelets, and nervous tissue. In nervous system, serotonin and its metabolites are under the control of the circadian timing system, but it is not known if daily variations of serotonin exist in the liver. To explore this possibility, we tested if the rhythmic pattern of serotonin metabolism was regulated by da...

We formalise the data race free (DRF) guarantee provided by Java, as captured by the semi-formal Java Memory Model (JMM) [1] and published in the Java Language Specification [2]. The DRF guarantee says that all programs which are correctly synchronised (i.e., free of data races) can only have sequentially consistent behaviours. Such programs can be understood intuitively by programmers. Formali...

Modern programming languages, such as C++ and Java, provide a sequentially consistent (SC) memory model for well-behaved programs that follow a certain synchronisation discipline, e.g., for those that are data-race free (DRF). However, performance-critical libraries often violate the discipline by using lowlevel hardware primitives, which have a weaker semantics. In such scenarios, it is import...

BACKGROUND Distal radius fractures (DRFs) are one of the most common injuries among the elderly, resulting in significant expense and disability. The specific aims of this study are (1) to examine rates of therapy following DRFs and (2) to identify those factors that influence utilization of therapy and time span between DRF treatment and therapy among a national cohort of elderly patients. M...

We analyse the validity of common optimisations on multi-threaded programs in two memory models—the DRF guarantee and the Java Memory Model. Unlike in the single-threaded world, even simple program transformations, such as common subexpression elimination, can introduce new behaviours in shared-memory multi-threading with an interleaved semantics. To validate such optimisations, most current pr...

Studies in cognitive psychology showed that personality (openness to experience, thin boundaries, absorption), creativity, nocturnal awakenings, and attitude toward dreams are significantly related to dream recall frequency (DRF). These results suggest the possibility of neurophysiological trait differences between subjects with high and low DRF. To test this hypothesis we compared sleep charac...

The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor (GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell surface-expressed chemokine ligand 16 (CXCL16), and also regulates leukocyte migration by interacting with the soluble shed variant of CXCL16. In contrast to virtually all other chemokine receptors with chemotactic activit...

Global aerosol direct radiative forcing (DRF) is an important metric for assessing potential climate impacts of future emissions changes. However, the radiative consequences of emissions perturbations are not readily quantified nor well understood at the level of detail necessary to assess realistic policy options. To address this challenge, here we show how adjoint model sensitivities can be u...

BACKGROUND Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diaphanous inhibitory domain (DID). METHODOLOGY/PRINCIPAL FINDINGS Here we report the crystal struct...