OBJECTIVE Our objective was to determine whether Seville orange juice produces a grapefruit juice-like interaction with felodipine and whether bergamottin, 6',7'-dihydroxybergamottin, or other furocoumarins are involved. METHODS In a randomized three-way crossover design, 10 volunteers received a felodipine 10-mg extended-release tablet with 240 mL of Seville orange juice, dilute grapefruit j...

The Corona pandemic has affected the entire world. It caused a fatal respiratory illness and threatened public safety human health. Scientists scrambled to detect an operative drug counter SARS-CoV-2 (severe acute syndrome Coronavirus 2). hunt for nutritional supplement treat occupied large area of scientific inquiry. Grapefruit (GF) (Rutaceae family) is subtropical fruit, it potent bioactive p...

A method for the determination of three furocoumarins containing two new chemicals (GF-I-1 and GF-I-4) in commercially available grapefruit juice and grapefruit itself was developed using high-performance liquid chromatography (HPLC). These components isolated from grapefruit juice have 5-geranyloxyfurocoumarin dimer structures showing extremely high affinities for a form of cytochrome P450 (CY...

The bioactivity of Israeli Jaffa blond (Shamouti) fresh orange and Israeli Jaffa red Star Ruby (Sunrise) grapefruit juices was investigated in vitro and in vivo. The contents of bioactive compounds of these juices were determined. The influence of bioactive compounds on plasma lipids and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets was assessed. Sign...

Tangelos are citrus hybrids with grapefruit and tangerine parentage and are a significant crop in Florida, marketed as specialty fruit. Because tangelos contain genetic material from grapefruit, there is the question of whether or not they contain furanocoumarins and exhibit an interaction with the drugs that have been associated with the grapefruit-drug interaction. Authentic samples of 13 tan...

Grapefruit juice produces mechanism-based inhibition of intestinal drug metabolism when consumed in normal quantities. This can produce clinically important increases in oral drug bioavailability when coadministered with substrates of cytochrome p450 3A4 (CYP3A4) that undergo high presystemic metabolism. Furanocoumarins such as bergamottin and 6',7'-dihydroxybergamottin have been identified as ...

Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P - 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P - glycoprotein pump, found in the brush border of the intestinal wall which transports many of these...

this study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine a in rats. forty male sprague-dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. water or juices (10 ml/kg) were given orally twice a day for 3 days. three hours after the 5 th dose, cyclospori...