Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) (PL) is a naturally occurring yellow pigment found in the plants of the Plumbaginaceae, Droseraceae, Ancistrocladaceae, and Dioncophyllaceae families. It has been reported that PL exhibits anticarcinogenic, anti-inflammatory, and analgesic activities. However, the mechanism underlying its anti-inflammatory action remains unknown. In the current ...

Introduction: Previously, we demonstrated that i.p. injection of aqueous extract prepared from aerial parts of Drosera Spatulata (Droseraceae) can induced remarkable analgesia in both phases of formalin test in rats. Because, analgesia induced in acute phase of formalin test mainly mediated by activation of central analgesic mechanisms and also paragigantocellularis (PGi) nucleus is part of bra...