A general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. Anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. Alkylation of methyl cyanoacetate which was perfo...

Drug-drug interactions (DDIs) are defined as clinically meaningful alterations in the exposure and response to a drug (called object drug) that has occurred as a result of the co-administration of another drug (called precipitant drug). According a 2011 study, drug-drug interactions (DDIs) are responsible for roughly 220,000 hospital admissions per year (Percha and Altman 2013). However, this n...

a general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. alkylation of methyl cyanoacetate which was perfo...