HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with...

Neuroendocrine differentiation has been reported in both in situ and infiltrating breast cancers. The prognostic significance of neuroendocrine differentiation in mammary carcinoma is unclear. The spectrum ranges from undifferentiated small cell carcinoma to ductal carcinoma in situ with neuroendocrine differentiation. Mucinous carcinomas of the breast appear to have the greatest association wi...

Background The prognostic implication of concomitant ductal carcinoma in situ (DCIS) in invasive ductal carcinoma (IDC) remains controversial. Our objective was to investigate whether concomitant DCIS affects survival outcomes in patients with IDC. Materials and methods Patients with nonmetastatic breast cancer who underwent surgery in 2010-2014 were included from the Surveillance, Epidemiolo...

Primary ectopic breast carcinoma in male is very rare. We report a case on a 52-year-old gentleman who presented initially with bilateral lesions in his axilla and after delayed diagnosis the right lesion was confirmed as an ectopic breast carcinoma. We reviewed the literature and discussed the significance of the case.

The aim of our research is to identify potential genes associated with Ductal carcinoma in situ (DCIS) through microarrays. The microarray dataset GS54665 were downloaded from the GEO(Gene Expression Omnibus) database. Dysregulated genes were screened and their associations with DCIS was analyzed by comprehensive bioinformatics tools. A total of 649 differential expression genes were identified...

Ductal carcinoma in situ of the breast is associated with low mortality rates, but local relapse is a matter of concern in this disease. Risk factors for local relapse include young age, close or positive margins, and tumor necrosis. Whole breast irradiation following breast-conserving surgery for ductal carcinoma in situ significantly reduces the risk of local relapse as compared to breast-con...

IMPORTANCE While the prevalence of ductal carcinoma in situ (DCIS) of the breast has increased substantially following the introduction of breast-screening methods, the clinical significance of early detection and treatment for DCIS remains unclear. OBJECTIVE To investigate the survival benefit of breast surgery for low-grade DCIS. DESIGN, SETTING, AND PARTICIPANTS A retrospective longitudi...

PURPOSE Ductal carcinoma in situ (DCIS) is thought to be a nonobligate precursor of invasive cancer. Genomic changes specific to pure DCIS versus invasive cancer, as well as alterations unique to individual DCIS subtypes, have not been fully defined. EXPERIMENTAL DESIGN Chromosomal copy number alterations were examined by comparative genomic hybridization in 34 cases of pure DCIS and compared...

Researchers at Memorial Sloan-Kettering Cancer Center have investigated many aspects of their experience with ductal carcinoma in situ of the breast over the past 20 years. This paper summarizes the most clinically relevant findings.

Background: Ultrasound propagation velocity was measured experimentally in normal, fibroadenoma and ductal carcinoma breast tissues, in order to distinguish normal breast tissue from tumors. Materials and methods: In quantitative measurements of ultrasound velocity, 403 breast tissue images were selected, comprising 130 normal breast tissue, 130 fibroadenoma, and 143 ductal carcinoma tumors. Th...