نتایج جستجو برای: duffy binding protein
تعداد نتایج: 1447864 فیلتر نتایج به سال:
In the war against Plasmodium, humans have evolved to eliminate or modify proteins on the erythrocyte surface that serve as receptors for parasite invasion, such as the Duffy blood group, a receptor for Plasmodium vivax, and the Gerbich-negative modification of glycophorin C for Plasmodium falciparum. In turn, the parasite counters with expansion and diversification of ligand families. The high...
The variant surface antigen VAR2CSA is a pregnancy malaria vaccine candidate, but its size and polymorphism are obstacles to development. We expressed 3D7-type VAR2CSA domains in Escherichia coli as insoluble His-tagged proteins (Duffy binding-like [DBL] domains DBL1, DBL3, DBL4, and DBL5) that were denatured and refolded or as soluble glutathione S-transferase-tagged protein (DBL6). Anti-DBL5 ...
SummaryObjectives Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was evaluate the impact of maternal HIV infection and placental malaria on cord blood levels efficiency transfer IgG subclasses. Methods In a cohort 341 delivering HIV-negative HIV-positive mothers from southern Mozam...
the binding of drugs by plasma proteins is an important phenomenon, because it influences the size of the free fraction of the drugs in plasma. in this study the influence of dipyridamole (dp) on the protein binding of propranolol (pl) and pl on the protein binding of dp were studied alone and in the presence of nicotine (nc). the equilibrium dialysis was employed for protein binding stu...
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