BACKGROUND Measurement of faecal elastase (FE1) is used widely to screen for pancreatic exocrine insufficiency (PI). FE1 does not allow differentiation of primary from secondary PI. AIMS To investigate the relation between duodenal morphology and FE1 in children with secondary PI resulting from primary gastrointestinal diseases. METHODS A group of 51 children underwent small intestinal biop...

Beginning with Gee's7 mention of atrophy of glandular crypts in 1888, many investigators of idiopathic sprue agreed that the significant changes in the small bowel at autopsy consisted of mucosal and villous atrophy, edema, and chronic mucosal inflammation and ulceration. Later, these observations were dismissed by Thaysene as due to post-mortem autolysis. According to Suarez et al.,' Koppisch ...

We determined the incidence of gastric metaplasia in the duodenal bulb of duodenal ulcer patients and the Helicobacter pylori (H. pylori) infection rate at sites with gastric metaplasia. Biopsy of the duodenal bulb showed the presence of gastric metaplasia in 61 of 86 patients (71%) overall and in 18 of 47 patients (38.3%) who had gastrectomy at an early gastric cancer. The histological diagnos...

OBJECTIVE To test the effectiveness of serologic antigliadin antibody (AGA) testing in predicting celiac disease in children. DESIGN Prospective clinical assessment. SETTING Hôpital Sainte-Justine, montreal. PATIENTS A total of 176 children with possible celiac disease who were referred for duodenal biopsy between January 1992 and June 1995. OUTCOME MEASURES IgA and IgG AGA titres, as d...

BACKGROUND The British Society of Gastroenterology guidelines recommend taking at least four duodenal biopsy specimens at the time of upper gastrointestinal (UGI) endoscopy if coeliac disease (CD) is suspected and it has been shown to increase the diagnostic yield of CD. We assessed the compliance to these guidelines within our institution. We then applied measures to improve our compliance rat...

Background and study aim: Duodenal mucosal lesions are usually difficult to diagnose. White light endoscopy(WLE) ‎generally does not visualize the duodenal villous patterns properly miss small ‎elevated lesions, which result in an inaccurate diagnosis. We aimed assess ‎diagnostic accuracy of I-scan technology for evaluation histological confirmation ‎mucosal duodenum its role biopsy targeting‎....

OBJECTIVE To assess the management of patients with coeliac disease in relation to a change in diagnostic method from jejunal suction biopsy to endoscopic biopsy. DESIGN 16 item questionnaire survey of consultant members of the British Society of Gastroenterology. SUBJECTS 359 consultant physician and gastroenterologist members of the society. MAIN MEASURES Type of routine biopsy; repeat ...

The development of intramural duodenal haematoma (IDH) after small bowel biopsy is an unusual lesion and has only been reported in 18 children. Coagulopathy, thrombocytopenia and some special features of duodenal anatomy, e.g. relatively fixed position in the retroperitoneum and numerous submucosal blood vessels, have been suggested as a cause for IDH. The typical clinical presentation of IDH i...

Helicobacter pylori associated duodenal ulcers occur in patches of gastric metaplasia. The pathogenesis of gastric metaplasia is unclear, but it has been produced in experimental animals by acute injury and has been shown to be present to a greater extent of H pylori positive subjects. This study aimed to discover if gastric metaplasia regressed with eradication of H pylori or healing of duoden...