Precise autonomous navigation remains a substantial challenge to all underwater platforms. Inertial Measurement Units (IMU) and Doppler Velocity Logs (DVL) have complementary characteristics and are promising sensors that could enable fully autonomous underwater navigation in unexplored areas without relying on additional external Global Positioning System (GPS) or acoustic beacons. This paper ...

Aquaculture net cage inspection and maintenance is a central issue in fish farming. Inspection using autonomous underwater vehicles promising solution. This paper proposes laser-camera triangulation for pose estimation to enable following an vehicle. The laser 3D data experimentally compared doppler velocity log (DVL) active farm. We show that our system comparable performance DVL distance angu...

For an underwater Strapdown Inertial Navigation System/Doppler velocity log (SINS/DVL) integrated navigation system, the short-term failure of DVL may lead to loss reliable external information from DVL, which will cause SINS errors accumulate. To circumvent this problem, paper proposes a predictor based on fuzzy multi-output least squares support vector machine (FMLS-SVM) predict measurements ...

Bone anabolic agents promoting bone formation and rebuilding damaged bones would ideally overcome the limitations of anti-resorptive therapy, the current standard prescription for osteoporosis. However, the currently prescribed parathyroid hormone (PTH)-based anabolic drugs present limitations and adverse effects including osteosarcoma during long-term use. Also, the antibody-based anabolic dru...

Recent evidence suggests that members of the Dickkopf (Dkk) family can directly bind to LDL-related protein (LRP)-6, resulting in inhibition of Wnt-activated signaling. To further characterize the interactions between Dkk and LRP proteins, conditioned media containing individually conserved cysteine-rich domains of Dkk-1 and Dkk-2 were prepared. Although full-length Dkk-1 and Dkk-2 and the seco...

Dishevelled (Dvl) proteins are important signaling components of both the canonical beta-catenin/Wnt pathway, which controls cell proliferation and patterning, and the planar cell polarity (PCP) pathway, which coordinates cell polarity within a sheet of cells and also directs convergent extension cell (CE) movements that produce narrowing and elongation of the tissue. Three mammalian Dvl genes ...

Abstract. Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with receptor Frizzled. Blocking Dvl PDZ–Frizzled interaction represents a potential approach for cancer treatment, which stimulated identification small-molecule inhibitors, among them anti-inflammatory drug Sulindac and Ky-02327. Aiming to develop tighter binding ...

The hypertrophic response of the heart has been recognized recently as the net result of activation of prohypertrophic and antihypertrophic pathways. Here we report the involvement of the Wnt/Frizzled pathway in the onset of cardiac hypertrophy development. Stimulation of the Wnt/Frizzled pathway activates the disheveled (Dvl) protein. Disheveled subsequently can inhibit glycogen synthase kinas...

Avenanthramides (AVEN) are major phenolic acids in oat (Avena sativa L.) that have potent antioxidant functions. Female Sprague-Dawley rats (n 48, age 6-7 wk) were fed either an AIN-93 based control (C) diet or the same diet containing 0.1 g/kg AVEN-Bc [N-(3',4'-dihydroxycinnamoyl)5-hydroxyanthranilic acid] for 50 days. Each group was further divided into rested (R) and exercised (E, treadmill ...

Sirtuin 1 (SIRT1) is a class III histone deacetylase that deacetylates histone and nonhistone proteins to regulate gene transcription and protein function. Because SIRT1 regulates very diverse responses such as apoptosis, insulin sensitivity, autophagy, differentiation, and stem cell pluripotency, it has been a challenge to reconcile how it orchestrates such pleiotropic effects. Here we show th...