نتایج جستجو برای: e2fs
تعداد نتایج: 164 فیلتر نتایج به سال:
E2F transcription factor 2 (E2F2) is a member of the family factors. The classical view that some E2Fs act as "activators" and others "inhibitors" cell cycle gene expression. However, so-called "activator" E2F2 particularly enigmatic, with seemingly contradictory roles in cycle, proliferation, apoptosis, inflammation, migration invasion. How can we rationalize apparently opposing functions diff...
The retinoblastoma protein pRB and its two homologs p130 and p107 form the family of pocket proteins and play a major role in cell-cycle regulation and suppression of human and mouse tumorigenesis. Pocket proteins regulate the activity of E2F transcription factors duringG1–S transition. Twomechanisms have been described: (i) pocket protein binding blocks the transactivation domain of activator ...
E2F transcription factors are required for the progression and arrest of the cell cycle in animals. Like animals, plants have evolved to conserve the E2F family. The Arabidopsis genome encodes E2F and DP proteins that share a high similarity with the animal E2F and DP families. Here, we show that Arabidopsis E2F and DP proteins are not predominantly localized to the nucleus in analyses with gre...
The retinoblastoma protein pRB and its two homologs p130 and p107 form the family of pocket proteins and play a major role in cell-cycle regulation and suppression of human and mouse tumorigenesis. Pocket proteins regulate the activity of E2F transcription factors during G1-S transition. Two mechanisms have been described: (i) pocket protein binding blocks the transactivation domain of activato...
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