Cervical cancer is the second most common cause of cancer death in women worldwide. It is almost invariably associated with infection with human papilloma virus (HPV) particularly types 16 and 18. The ubiquitous expression of E6 and E7 oncogene products has been recognised as an attractive target for CTL-mediated immunotherapy. In-vivo expansion of an HPV oncogene product specific MHC class 1 r...

We report a 35-year-old man with bladder carcinoma developing 2 months after urethral condyloma acuminatum, with an 8-year history of persistent human papilloma virus-58 infection in the urinary tract. DNA was extracted from paraffin-embedded tissue specimens. Human papilloma virus-6 and -58 were detected in the condyloma, whereas human papilloma virus-58 was detected in the carcinoma. In situ ...

A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both m...

High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins target E6TP1 for degradation. The HPV16 E6-induced degradation of E6TP1 strongl...

BACKGROUND Cervical cancer is the leading cause of death from cancer in under-developed countries. Human papilloma virus (HPV) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. Conventional Polymerase Chain Reaction (PCR), type-specific and consensus primer-based PCR followed by sequencing, Restriction Fragment Length Polymorphism (RFLP) or hybridization by sp...

In order to evaluate the potential application value of cidofovir (CDV) in the prevention of human papillomavirus (HPV) infection and treatment of cervical cancer, the inhibitory effect of CDV on the proliferation of HPV 18-positive HeLa cells in cervical cancer was preliminarily investigated, using cisplatin (DDP) as a positive control. An MTT assay was used to analyze the effects of CDV and D...

OBJECTIVE This study was to identify small inhibitory RNAs (siRNAs) that are effective in inhibiting growth of cervical cancer cell lines harboring human papilloma virus (HPV) and to examine how siRNAs interact with interferon beta (IFN-β) and thimerosal. METHODS The HPV18-positive HeLa and C-4I cell lines were used. Four types of siRNAs were designed according to their target (both E6 and E7...

carcinoma derived from the virus-induced rabbit papillontá has been the subject of numerous stud iss. Early work indicated that the carcinoma (V2) did not contain papilloma virus demonstrable by the usual infectivity tests. Nevertheless, there was reason to believe that papilloma antigen was pres cut in the V2 carcinoma cell, since the host rabbits developed specific papilloma complement-fixin...

abstract aims: a few studies concentrate on the level of knowledge of hpv. this study was conducted to evaluate the level of knowledge about hpv, its risk factors, and its relation with cervical cancer in women of kashan city, iran. instrument & methods: this descriptive cross-sectional study was conducted in january 2015 in the population of the women of kashan city, iran, and 200 persons were...

human papilloma virus causes benign and malignant abnormalities in different part of the body. the link between high risk types of hpv and some anogenital and aerodigestive tract cancer is well established. oral hpv infection plays a role in developing oropharyngeal squamous cell carcinoma. we studied the prevalence of oral hpv in healthy individuals and its relative risk factors.saliva samples...