2 This thesis has been accepted as part of the honors requirements in the Department of Biology. _____________________________________ ____________________ (advisor signature) (date) _____________________________________ ____________________ (reader signature) (date) 3 Introduction

Malaria is one of the world's most severe endemic diseases and due to the emergence of resistance to the currently available medicines, the need for new targets and relevant antimalarial drugs remains acute. The crude extract, four solvent fractions and two isolated compounds from the roots of Echinops hoehnelii were tested for their antimalarial activity using the standard four-day suppressive...

Graded Sonic hedgehog signaling may generate neuronal diversity in the ventral spinal cord in two steps: the creation of a generic population of ventral progenitors, followed by the Pax6-dependent generation of distinct subpopulations within these ventral progenitors.