Bacterial genomes are transcribed by DNA-dependent RNA polymerase (RNAP), which achieves gene selectivity through interaction with sigma factors that recognize promoters, and transcription factors (TFs) that control the activity and specificity of RNAP holoenzyme. To understand the molecular mechanisms of transcriptional regulation, the identification of regulatory targets is needed for all the...

Recent reports have indicated that small RNAs have key roles in the response of the E.coli to stress and also in the regulating of virulence factors. It seems that some small non-coding RNAs are involved in multidrug resistance. Previous studies have indicated that rprA can increase the tolerance to Kanamycin in RcsB-deficient Escherichia coli K-12 following osmotic shock. The current study aim...

*Professor, Department of Medicine, BYL Nair Hospital and TN College, Mumbai. **Hon. Asst. Prof., Department of Medicine, Grant Medical College & Sir JJ Group of Hospitals, Mumbai. One of the major success stores against infection diseases in the 20th Century is hampered by reemergence of old ones and with co-occurrence of new disease as well as drug resistance strains. Several bacterial diseas...

PURPOSE Stem cell factor (SCF) plays an important role in the survival, proliferation and differentiation of hematopoietic stem cells and progenitor cells. Potential therapeutic applications of SCF include hematopoietic stem cell mobilization, exvivo stem/progenitor cell expansion, gene therapy, and immunotherapy. Considering the cost and problem in accessibility of this product in Iran, clears...

This paper presents a new approach to the problem of multiclass classification. The proposed approach has the capability to provide an assessment of the uncertainty value associated with the results of the prediction. Two feed-forward backpropagation neural networks, each with multiple outputs, are used. One network is used to predict degrees of truth membership and another network is used to p...

Clustered regularly interspaced short palindromic repeat (CRISPR) is a recently discovered adaptive prokaryotic immune system that provides acquired immunity against foreign nucleic acids by utilizing small guide crRNAs (CRISPR RNAs) to interfere with invading viruses and plasmids. In Escherichia coli, Cas3 is essential for crRNA-guided interference with virus proliferation. Cas3 contains N-ter...

In the environment, many microorganisms coexist in communities competing for resources, and they are often associated as biofilms. The investigation of bacterial ecology and interactions may help to improve understanding of the ability of biofilms to persist. In this study, the antibacterial and antibiofilm activities of extract Capsicum annuum L on the growth and biofilm formation of common pa...

DNA derived from various human malignant and non-malignant tissues was hybridized with radioactive complementary R N A (cR N A ) synthetized in vitro with the aid of Ecoli-RNA-polymerase by using DNA of human herpes group viruses as templates. Epstein-Barr virus (EB V ) -specific c R NA annealed significantly with DNA from nasopharyngeal carcinoma biopsies as well as with DNA preparations from ...