Cognitive and emotional capabilities were evaluated in 73 female patients with stable relapsing-remitting definite, and/or laboratory-supported multiple sclerosis (MS) and were compared with 32 matched healthy controls. Patients were categorized according to their score in the expanded disability status scale (EDSS) to either no (EDSS 0, n = 33) or few clinical signs (EDSS 1-2, n = 40) of MS wi...

The acquisition of a reliable and valid outcome measure in multiple sclerosis (MS) is one of the holy grails for clinician researchers working in the field. The current standard for measuring MS-related disability is the Expanded Disability Status Scale (EDSS), a nonlinear scale ranging from 0 (normal neurologic examination) to 10 (death due to MS) [1]. Widely incorporated into MS clinical tria...

INTRODUCTION This study investigates the application of texture analysis methods on brain T2-white matter lesions detected with magnetic resonance imaging (MRI) for the prognosis of future disability in subjects diagnosed with clinical isolated syndrome (CIS) of multiple sclerosis (MS). METHODS Brain lesions and normal appearing white matter (NAWM) from 38 symptomatic untreated subjects diagn...

OBJECTIVES To assess the magnitude of the correlations between disability and composite MRI scores in patients with MS. METHODS T2- and T1-weighted MRI, magnetization transfer imaging, diffusion tensor imaging, and MRS imaging scans of the brain from 23 patients with MS were obtained. T2 lesion volume, T1 lesion volume, brain magnetization transfer ratio, average brain diffusivity (D), and br...

There were 21 patients with rapidly progressive multiple sclerosis (MS) treated on a phase 1/2 study of intense immune suppressive therapy and autologous hematopoietic stem cell (HSC) support with no 1-year mortality. Following transplantation, one patient had a confirmed acute attack of MS. Neurologic progression defined by the expanded disability status scale (EDSS) did not increase in disabi...

BACKGROUND & OBJECTIVES Published natural history data on late-onset of multiple sclerosis are limited. We aimed to assess the risk of attaining EDSS 6.0 among patients with late-onset (> 40 years) MS (LOMS) and young-onset (18-40 years) MS (YOMS). METHODS This cross-sectional cohort study was conducted to identify LOMS and YOMS patients' with relapsing remitting course at MS diagnosis. Time ...

Enterprise-level energy delivery systems (EDSs) depend on different software or hardware vendors to achieve operational efficiency. Critical components of these are typically manufactured and integrated by overseas suppliers, which expands the attack surface adversaries with additional opportunities infiltrate into EDSs. Due this reason, risk management EDS supply chain is crucial ensure that w...

The Expanded Disability Status Scale (EDSS) has been the most widely used measure of disability in multiple sclerosis clinical trials. Although EDSS has the advantage of familiarity with respect to recent proposals, yet is difficult to use consistently between evaluators. AEDSS (Automatic EDSS) is a computerized system designed to overcome this problem. It constrains the neurologist to follow p...

BACKGROUND Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwMS). METHODS We interviewed 42 pwMS receiving natalizumab and collected clin...

We aimed to compare the therapeutic effect of Avonex (Av), Betaferon (Be) & Rebif (Re) on the Expanded Disability Status Scale (EDSS) in Multiple Sclerosis (MS). Ninety patients referring to Farshchian Hospital were entered in this study. The patients were divided into three equal groups: group 1 received Av, group 2 received Re and group 3 received Be, and after 24 months, comparison was done ...