Convenience of administration and patient compliance are gaining importance in the formulation of dosage forms. Many patients, like elderly people and person with dysphagia find difficulty to swallow the tablets and thus do not comply with prescriptions. So the present study was conducted to develop and formulate metformin effervescent granules. The stability study was carried out for 24 weeks ...

The main objective of the present study was to develop a multiple-unit, floating-pulsatile drug delivery system for obtaining no drug release during floating and in the proximal small intestine followed by pulsed, rapid drug release in distal small intestine to achieve chronotherapeutic release of indomethacin. The system developed consists of drug containing core pellets prepared by extrusion-...

Senna leaf (Cassia acutifolia) is a plant that widely known by the public to treat constipation. products have weaknesses in form of an unpleasant aroma and taste use inappropriate doses. This study aims determine effect variations levels lactose mannitol as filler on physical properties effervescent granules senna extract. Effervescent were made using melting method with ratio 25% : 75%, 50% 5...

The present study deals with formulation of a combined analgesic and antacid effervescent tablets. Paracetamol is the model drug used. It is poorly soluble in the water and hence the formulation is in the form of an effervescent tablet so that the disintegration time of the drug is not hindering the action. The mixture of magnesium and aluminium hydroxide is used as the model antacid. The prese...

ABSTRAK
 Sediaan effervescent merupakan cara lain pengembangan produk minuman ringan yang menarik dan memberikan variasi dalam penyajian karena selain praktis, dapat juga efek sparkle atau rasa seperti soda menutupi beberapa bahan tertentu tidak diinginkan. Manfaat Jamu Kunyit Asam jawa sudah terbukti secara empiris. berkhasiat sebagai antibiotik, pencegah sariawan, analgesik (meredakan ny...

Purpose: This study investigates the in-vitro gastroprotective activity of aqueous and ethanolic extracts Evolvulus alsinoides Linn plant formulates an antacid dosage form subsequently. Method: Extracts were prepared by refluxing activities then evaluated neutralising artificial gastric acid where effect as well capacity determined. The effervescent granular was formulated using freeze-dried po...

Objective: The objective of this investigation was to formulate and evaluate effervescent pellets febuxostat achieve sustain release effect.
 Place Duration Study: APMC College Pharmaceutical education research, Department Pharmaceutics, Himatnagar-383001, between June 2019 July 2021.
 Materials Methods: gastro retentive were formulated using Sodium CMC HPMC K4M HPMCK15M as a polymer....

OBJECTIVE To analyse the population pharmacokinetic-pharmacodynamic relationships of racemic ibuprofen administered in suspension or as effervescent granules with the aim of exploring the effect of formulation on the relevant pharmacodynamic parameters. DESIGN The pharmacokinetic model was developed from a randomised, cross-over bioequivalence study of the 2 formulations in healthy adults. Th...

The objective of present study was to develop effervescent tablets of promethazine (PMZ) for the treatment of emesis. Effervescent tablets were prepared by direct compression method and were optimized using 3 2 full factorial design. Amount to sodium starch glycolate(X1) and amount of sodium bicarbonate (X2) were selected as independent variables, whereas disintegration time (Y1), amount of car...