We found high endothelin-1 and von Willebrand factor plasma titers not only in two individuals (daughter and father) affected with Pseudoxanthoma elasticum but also in a young unaffected relative. These findings raise the possibility that these molecules could be the first biochemical fingerprints of this, still not clinically evident, rare inherited disorder of elastic tissue.

Cutis laxa, clinically characterized by loose and pendulous skin related to loss of elastic tissue, is a rare heterogeneous condition. It is classified into congenital and acquired types. We report a case of generalized acquired cutis laxa type 1 in a young man following pruritic urticarial plaques. We have done a brief review of literature.

BACKGROUND Adults with obesity or type 2 diabetes mellitus (T2DM) are at higher risk for stroke and myocardial infarction. Increased carotid intima-media thickness (cIMT) and stiffness are associated with these adverse outcomes. We compared carotid arteries in youth who were lean, were obese, or had T2DM. METHODS AND RESULTS Carotid ultrasound for cIMT measurement was performed, the Young ela...

Aging decreases the distensibility of large elastic arteries; however, the effects of age on the functional parameters of muscular, medium-sized arteries are not well determined. This study evaluated the consequences of aging on the functional parameters of the carotid and radial arteries in normotensive men. A total of 62 elderly subjects (aged 74+/-2 years) were compared with 87 young subject...

in the current paper, finite element method is employed for numerical simulations and the study of influential parameters on elastic modulus of polymer-matrix nano-composites. effects of different key parameters including particle elastic modulus, interphase elastic modulus, matrix elastic modulus, interphase thickness and particle volume fraction on total elastic modulus of nano-composite mate...

R isk factors for larger arterial diameters and enhanced wall thickening have been insufficiently assessed in young adults, an age-group where preventive measures have the greatest impact. Larger vessel diameter and wall thickening may represent underlying vascular remodeling, a dynamic process by which the vascular system attempts to compensate for vascular damage (1). The purpose of the curre...

reservoir characterization plays an important role in different parts of an industrial project. the results from a reservoir characterization study give insight into rock and fluid properties which can optimize the choice of drilling locations and reduce risk and uncertainty. delineating hydrocarbon bearing zones within a reservoir is the main objective of any seismic reservoir characterization...

Rate-independent evolution for material models with nonconvex elastic energies is studied without any spatial regularization of the inner variable; due to lack of convexity, the model is developed in the framework of Young measures. An existence result for the quasistatic evolution is obtained in terms of compatible systems of Young measures. We also show as this result can be equivalently refo...

We investigated the effects of aging on the elastic properties of lung tissue and the chest wall, simultaneously quantifying the contribution of each component to static inspiratory muscle work in resting and exercising adults. We further evaluated the interaction of aging and habitual physical activity on respiratory mechanics. Static lung volumes and elastic properties of the lung and chest w...

We tested the hypothesis that superoxide signaling within aortic perivascular adipose tissue (PVAT) contributes to large elastic artery stiffening in old mice. Young (4-6 months), old (26-28 months), and old treated with 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL), a superoxide scavenger (1 mm in drinking water for 3 weeks), male C57BL6/N mice were studied. Compared with young, old ...