BACKGROUND/AIMS Although the National Kidney Disease Education Program recommends use of the modification of diet in renal disease (MDRD) formula to estimate the glomerular filtration rate (GFR), most drug-dosing recommendations and clinical practices employ the Cockcroft-Gault (CG) formula. The quality score of the original MDRD study was better than that of the original CG study, although the...

BACKGROUND/AIMS In diabetics, cataract is associated with higher risk of death. In non-diabetics the data are conflicting, but some indicate an association between one type of cataract (nuclear) and increased mortality. The aim of this study was to estimate and compare age and sex specific mortality for elderly people with and without cataract in a population based cohort. METHODS A random sa...

OBJECTIVE APOE gene variants may contribute to the risk of chronic kidney disease. Our aim was to determine whether the common APOE-ε2/ε3/ε4 polymorphism is associated with a reduced estimated glomerular filtration rate (eGFR) in the RENASTUR population, a cohort of elderly individuals from the region Asturias (northern Spain). METHODS A total of 743 Spanish Caucasians aged 55-85 years were g...

Infections are a major cause of morbidity and mortality in the elderly. Improvements in health care prevention including vaccinations and treatment have led to an increase in the birth life expectancy. The vaccines that are now recommended for people over 60 are influenza, herpes zoster and a vaccine combining tetanus toxoid, reduced diphtheria toxoid, and pneumococcal vaccine. Our aim was to e...

The aim of the study was to determine the serum levels of soluble adhesion molecules and hs-CRP in elderly diabetics with mild cognitive impairment (MCI) alone or with depressive symptoms. Methods. 219 diabetics elders were screened for psychiatric disorders and divided: group 1, MCI without depressive mood; group 2, MCI with depressive mood; group 3, controls. Data of biochemical parameters an...

A study was carried out to find out whether more intense treatment (both medical and revascularisation) is targeted towards higher-risk patients with acute coronary syndromes. A prospective UK registry of patients admitted with non-ST elevation acute coronary syndromes was established to examine practice patterns and clinical outcomes with respect to the risk profile of the patients. Clinically...

Regular exercise may prevent or delay the development of Type 2 Diabetes Mellitus (T2DM). In addition to moderate- vigorous-intensity exercise, daily physical activity is also important for prevention and management T2D. Elderly diabetics (50-70 years) were selected from PSG Hospitals - a multi-specialty hospital. A Self-Management Questionnaire (DSMQ) was developed be locally relevant. The val...

background: diabetic peripheral neuropathy (dpn) accounts for 80% of diabetic foot ulceration; therefore neurologic examination plays a critical role in screening at risk patients. our objective was assessment the prevalence of dpn and related factors based on clinical findings. methods: this cross-sectional study was conducted on 124 diabetics who were randomly recruited from diabetes clinic o...