This study investigated the effects of age on a random generation task. In Experiment 1, young and elderly subjects were asked to generate random strings of letters at 1-, 2-, and 4-s rates. The elderly subjects produced more alphabetical stereotype responses than young subjects, even in the slowest rate condition. Furthermore, as faster rates were imposed, elderly subjects could no longer main...

BACKGROUND AND OBJECTIVES There is lack of published data on bulbar signs among the healthy population. This study aims to determine the range of normality of bulbar signs particularly among the elderly. METHODS Systemic examination of bulbar signs was carried out according to a predetermined protocol on a cohort of young and elderly healthy subjects. RESULTS A total of 206 subjects were re...

The 23-valent pneumococcal polysaccharide vaccine was formulated to prevent invasive infection in the elderly and other high-risk populations from the most prevalent Streptococcus pneumoniae serotypes. However, the immunogenicity of all 23 vaccine polysaccharides has not been fully characterized in elderly adults. We previously reported that whereas the majority of elderly subjects had vigorous...

BACKGROUND The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals. METHODS Fourteen young, female, healthy never-smokers were recruited via public postings. Twelve elderly female healthy never-smokers were recruited from a nursing home residence. The c...

The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, usin...

BACKGROUND AND OBJECTIVE An increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and pharmacodynamic effects of prasugrel at the clinical dose used in Japan in healthy Japanese elderly subjects compared with non-elderly subjects. M...

Elderly adults consume more metabolic energy during walking than young adults. Our study tested the hypothesis that elderly adults consume more metabolic energy during walking than young adults because they perform more individual limb work on the center of mass. Thus we compared how much individual limb work young and elderly adults performed on the center of mass during walking. We measured m...

malnutrition and depression are highly prevalent in the elderly and can lead to unfavorable outcomes. the aims of the current study were to determine the association between malnutrition and depression and also to find any correlation of depression with some anthropometric indices in free living elderly.in this cross-sectional study, 337 elderly subjects (193 females) were selected using cluste...

[Purpose] This study compared the center of force (COF) trajectory during sit-to-stand (STS) movements performed by elderly and old-old elderly subjects. [Subjects] We recruited 9 elderly and 10 old-old elderly subjects with no knee joint pain or lower limb orthopedic problems. [Methods] The CONFORMat system was used to measure the length of the COF trajectory as the subjects performed the STS ...

Walking stability of human beings varies with age and reduces in the elderly people. Lesser walking stability causes many falls in the elderly people. In this paper, we have investigated the walking stability of young and elderly subjects using approximate entropy, a non-linear time series analysis method. Our emphasis in this paper is to investigate the walking stability using a portable instr...