The authors explored the possibility that there are different neural consequences, beyond the primary site of brain damage, following perirhinal cortex (PRh) lesions made in different ways. Fos expression was used as a marker for neuronal activation and compared across the forebrains of rats that underwent the different types of surgery. Electrolytic and excitotoxic PRh lesions produced dramati...

AGGLETON, J. P., M. PETRIDES AND S. D. IVERSEN. Differential effects ofamygdaloid lesions on conditioned taste aversion learning by rats. PHYSIOL. BEHAV. 27(3) 397-400, 1981.--Rats with electrolytic lesions placed in either the basolateral or corticomedial divisions of the amygdala acquired a conditioned taste aversion to sucrose. Comparisons with a surgical control group indicated that damage ...

A B S T R A C TIntroduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM). Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally micr...

Bilateral electrolytic lesions were placed in the median eminence area of the hypothalamus in 12-week-old male Wistar rats. Sham-operated and untreated control rats were also included. Two weeks later, one-half of them were given 0.03% N-2-fluorenylacetamide incorporated into the diet for 16 weeks with adequate resting periods in between. The animals were killed 34 weeks after the last carcinog...

Rats received electrolytic lesions centered in the gustatory subnucleus of the ventral posterior complex of the thalamus. They were tested for impairments of the ability to increase sodium chloride intake after depletion of body sodium or treatment with the mineralocortieoid desoxycorticosterone. Tests were administered either within a few weeks or after 2 months postoperative recovery to test ...

It was found previously that unilateral electrolytic and 6-OHDA lesions of the ventral tegmental area (VTA) and unilateral intra-VTA injection of bicuculline resulted in facilitation of behavioral responses evoked by electrical stimulation of the symmetrical VTA area in the contralateral hemisphere. We postulated that "the contralateral facilitation effect", which may reflect the yet unexplored...

Unilateral damage to the forelimb representation area of the sensorimotor cortex (SMC) results in a compensatory reliance on the unimpaired (ipsilateral to the lesion) forelimb as well as reorganization of neuronal structure and connectivity in the contralateral motor cortex. Recently, male rats with unilateral electrolytic SMC lesions were found to have enhanced skilled reaching performance wi...

Previous studies by this laboratory have shown that an electrolytic lesion of tissue surrounding the anteroventral third cerebral ventricle (AV3V) produces pressor deficits to both intravenously (i.v.) and intracerebroventricularly (i.c.v.) administered angiotensin II (AII). These studies were designed to identify the neural substrates critical to the central AII pressor response. The AII press...

Small electrolytic lesions placed in the hilus of the dentate gyrus have been shown to induce behavioral seizures, an elevation in the concentration of the opioid peptide enkephalin, and an increase in the transcription of the gene coding for the peptide precursor of enkephalin. Since polyamines and ornithine decarboxylase (ODC), the rate-limiting enzyme in their synthesis, have been shown to p...