OBJECTIVE To determine whether prolonged vascular endothelial growth factor inhibition is toxic to the retina by using pattern electroretinographic imaging in participants with neovascular age-related macular degeneration (AMD). METHODS We performed a prospective, single-arm clinical trial of 17 eyes in 17 treatment-naive participants with subfoveal choroidal neovascularization from AMD. On-l...

Electroretinography is a mainstay of clinical ophthalmic diagnostic testing. The electroretinogram, or ERG, provides an objective, quantitative measure of retinal function and allows the clinician to monitor the function of rod cells, cone cells, and ganglion cells in each eye. It uses electrodes placed on the cornea or adjacent to the orbit to monitor changes in the electrical potential of the...

The noncorneal ERG is essential for certain patients in which corneal recording is contraindicated. A preliminary report is presented investigating ERGs from three noncorneal montages and their correlation with the corneal ERG. Statistical analysis showed that an electrode at the medial canthus combined with medial viewing gave the closest correlation to the corneal ERG. Repeatability was good ...