BACKGROUND AND OBJECTIVE Prostate cancer is the second leading cause of death in men. The localized disease often responds to conventional therapies like androgen ablation via castration and/or administration of chemical inhibitors but advanced disease resistant to any curative therapies is still challenge for investigators. There are increasing efforts to enhance the possibility of finding pos...

Adenovirus-based gene therapy may provide an alternative mode of treatment for prostate cancer, especially for late-stage and androgen-independent disease for which there is currently no effective treatment. Efficient adenovirus infection of target cells depends upon the presence of the coxsackie adenovirus cell surface receptor, CAR, which is the primary receptor for group C adenoviruses and i...

background: nowadays, there is an increase of meat and animal carcass consumption worldwide. due to the economic value of meat, the likelihood of using unauthorized tissue is possible in meat products. based on these observations, the aim of the present study was to apply morphological method for detection of unauthorized tissues in processed meat products.  methods: in this study, a total of 2...

Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer. Using real-time methylation-specific PCR, we assessed the extent of hypermethylation at 16 CpG islands in DNA from seven prostate cancer cell lines (LNCaP, PC-3, DU-145, LAPC-4, CWR22Rv1, VCaP, and C42B), normal prostate epithelial cells, normal prostate stromal cells, 73 primary prostate cancers, 9...

Background: Nowadays, there is an increase of meat and animal carcass consumption worldwide. Due to the economic value of meat, the likelihood of using unauthorized tissue is possible in meat products. Based on these observations, the aim of the present study was to apply morphological method for detection of unauthorized tissues in processed meat products.  Methods: In this study, a to...

Andrographis paniculata has been studied for their potential protective action on benign prostate hypertrophy (BPH). This polyphenol reported to repair the antioxidant defense mechanisms in prostate, reduce inflammation, and inhibit IGF-I IGF-II. its (BPH) ability inflammation prostate. study aimed explore various scientific evidence related exploration of management These three studies consist...

Endothelial cell-specific molecule 1 (ESM1) is a major prognostic marker of several tumor types, but its value as a marker for prostate cancer is unknown. The purpose of the present study was to measure the relationship of ESM1 expression with androgen receptor (AR) expression and with Gleason score in human prostate carcinoma tissue. Expression of ESM1 and AR were determined by immunohistochem...