We provide comprehensive identification of embryonic (E15) and adult rat lateral ventricular choroid plexus transcriptome, with focus on junction-associated proteins, ionic influx transporters and channels. Additionally, these data are related to new structural and previously published permeability studies. Results reveal that most genes associated with intercellular junctions are expressed at ...

Complex barriers at the brain's surface, particularly in development, are poorly defined. In the adult, arachnoid blood-cerebrospinal fluid (CSF) barrier separates the fenestrated dural vessels from the CSF by means of a cell layer joined by tight junctions. Outer CSF-brain barrier provides diffusion restriction between brain and subarachnoid CSF through an initial radial glial end feet layer c...

The insulin like growth factors (IGFs) first appeared early in phylogeny about 600 million years ago and have increased in number through gene duplication. In mammals IGFs express in all tissues and are found in many biological fluids. IGF-1 has an important role during central nervous system (CNS) development. IGF-1 promotes differentiation, proliferation and prevents apoptosis of neuronal and...

INTRODUCTION The neurotoxic effects of cerebrospinal fluid (CSF) from patients with amyotrophic lateral sclerosis (ALS) have been reported by various authors who have attributed this neurotoxicity to the glutamate in CSF-ALS. MATERIAL AND METHODS Cultures of rat embryonic cortical neurons were exposed to CSF from ALS patients during an incubation period of 24 hours. Optical microscopy was use...

A conserved DNA sequence element, termed cytokine 1 (CK-1), is found in the promoter regions of many hemopoietic growth factor (HGF) genes. Mutational analyses and modification interference experiments show that this sequence specifically binds a nuclear transcription factor, NF-GMa, which is a protein with a molecular mass of 43 kilodaltons. It interacts with different affinities with the CK-1...

The insulin like growth factors (IGFs) first appeared early in phylogeny about 600 million years ago and have increased in number through gene duplication. In mammals IGFs express in all tissues and are found in many biological fluids. IGF-1 has an important role during central nervous system (CNS) development. IGF-1 promotes differentiation, proliferation and prevents apoptosis of neuronal and...

The insulin like growth factors (IGFs) first appeared early in phylogeny about 600 million years ago and have increased in number through gene duplication. In mammals IGFs express in all tissues and are found in many biological fluids. IGF-1 has an important role during central nervous system (CNS) development. IGF-1 promotes differentiation, proliferation and prevents apoptosis of neuronal and...

The insulin like growth factors (IGFs) first appeared early in phylogeny about 600 million years ago and have increased in number through gene duplication. In mammals IGFs express in all tissues and are found in many biological fluids. IGF-1 has an important role during central nervous system (CNS) development. IGF-1 promotes differentiation, proliferation and prevents apoptosis of neuronal and...