Abstract Background The present randomized clinical trial evaluated the efficacy of a topical lidocaine-prilocaine cream (EMLA) to relief pain during spinal puncture in pediatric oncology patients. Materials and Methods Sixty patients with malignancy candidate for spinal puncture were selected for this study. The patients were randomly allocated to two groups. Group A had topical EMLA cream...

Background: Venous cannulation is the most commonly performed invasive procedure in hospital patients. It is painful and associated with a high incidence of vasovagal reactions and pressor responses in patients. Objectives: The aim of the study is to evaluate the efficacy of eutectic mixture of local anesthetic cream in producing dermal analgesia for venous cannulation. Material and Method: 200...

BACKGROUND Venous leg ulcers affect up to 1 per cent of people at some time in their life. These ulcers are often painful and some clinicians choose dressings to reduce the pain both during and between dressing changes. OBJECTIVES To assess the effectiveness of dressings, local anaesthetics/analgesics for pain relief in venous leg ulceration. SEARCH STRATEGY Cochrane Wounds Group Register a...

PURPOSE The purpose of this investigation was to compare the pain responses of children during local anesthetic infiltration at bilateral palatal sites prepared with the topical application of benzocaine 20% oral adhesive (Orabase-B) versus benzocaine 20% gel (Hurricaine) or EMLA 5% oral adhesive (EMLA 5% cream in Orabase Plain). METHODS Forty subjects, aged 7-15 years old, received bilateral...

BACKGROUND With the emergence of new laser and dermatologic procedures, the need for more effective topical anesthesia continues to grow. There are now several topical anesthetics that are being used prior to laser and surgical procedures. OBJECTIVE To compare the degree and duration of anesthesia produced by four commonly used topical anesthetics, we performed a prospective study investigati...

Although the use of injectable anesthesia prior to subgingival scaling and root planing (SRP) reduces pain, many patients report fear and prolonged numbness of adjacent tissues. The aim of the present study was to compare the effects of a eutectic mixture containing 25 mg/g of lidocaine and 25 mg/g of prilocaine, injectable 2% lidocaine, topical 2% benzocaine and a placebo substance on reducing...

Calcium deficiency in apple fruit has been identified as a primary cause of bitter pit in apples, however some apples are not as susceptible as others. The apple cultivar ‘Scilate’ has been identified as less susceptible to bitter pit, but it is not known whether high calcium concentrations are what contribute this resistance. Because scilate is a more recent variety, little research has been d...

Background: The objectives were to determine whether a eutectic mixture of local anesthetic (EMLA) or placebo cream reduces pain during extracorporeal piezoelectric shock wave lithotripsy (EPSWL), and to determine which of the components of the application (i.e., the occlusive dressing, the cream, or the local anesthetic) contributes to analgesia. Methods: A randomized, double blind, crossover ...

BACKGROUND Pregnancy is associated with reduced local anesthetic requirements and increased pain thresholds, possibly due to hormonal changes and activation of endogenous opioids. METHODS We compared the responses to a mechanical and an electrical stimulus in 30 pregnant women (pregnant group) scheduled for cesarean section and 30 healthy female volunteers (control group) matched for age. Pai...