Local anesthetic creams for the clinical treatment of conditions such as postherpetic neuralgia were prepared as an in-house formulation from the eutectic mixture of lidocaine-tetracaine (LT cream) using two eutectic mixtures of local anesthetic (EMLA) type bases. The LT formulation was compared with a lidocaine-prilocaine (LP cream) eutectic mixture formulated using the same base as EMLA. The ...

OBJECTIVES To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i). MATERIAL AND METHODS In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamento...

The analgesic effect and the usefulness of EMLA cream 5% in connection with venous blood-sampling was investigated in 42 Tanzanian schoolchildren. Approximately 2.5 g EMLA was applied to the right cubital fossa for a minimum of 120 min. The analgesic effect was pronounced--93% of the venepunctures were pain-free and no child experienced severe pain. No adverse reactions were observed and the ch...

a number of studies has shown that orally administered sweet-tasting solutions reduce signs of pain during painful procedures. the local anesthetic cream emla has recently been shown to be safe for use in neonates. the present study aimed to compare the pain-reducing effect of emla cream with that of orally administered glucose during venipuncturing in newborns in yazd city. a randomized, contr...

BACKGROUND Untreated immunization pain causes undue distress and contributes to underimmunization through physician, and possibly parental, resistance to multiple simultaneous injections. OBJECTIVE To compare the efficacies of two pain management methods in reducing immediate immunization injection pain and distress in school-aged children. DESIGN A randomized, controlled clinical trial of ...

background to alleviate stinging pain in the skin entry area and visceral discomfort in patients who are undergoing eswl. objectives this study was designed to investigate the effectiveness of the emla cream in combination with remifentanil patient-controlled analgesia (pca) in patients undergoing eswl treatment. patients and methods sixty patients were divided into two double-blind randomized ...

PURPOSE This study compared the efficacy of commonly used topical anesthetics using an objective measuring scale. METHODS The following were tested: 5% EMLA cream, 10% cocaine, 10% lidocaine, 10% benzocaine, 1% dyclonine, and a placebo. A special instrument was designed to serve the purpose of pressure application on the gingiva to obtain a threshold discomfort level in grams before and after...

BACKGROUND Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is potentially painful, it is usually performed without the provision of analgesia, so compromising animal welfare. Furthermore, current means to assess pain in rabbits are poor and more reliable methods are required. The objectives...

PURPOSE The purpose of this investigation was to compare the pain responses of children during local anesthetic infiltration at bilateral palatal sites prepared with the topical application of benzocaine 20% oral adhesive (Orabase-B) versus benzocaine 20% gel (Hurricaine) or EMLA 5% oral adhesive (EMLA 5% cream in Orabase Plain). METHODS Forty subjects, aged 7-15 years old, received bilateral...

PURPOSE To compare the clinical efficacy between locally applied diclofenac diethylamine gel, EMLA cream and systemically given diclofenac sodium for the pain relief during extracorporeal shock wave lithotripsy (SWL) using Dornier Delta Compact Lithotripter. MATERIAL AND METHODS One hundred five patients with renal stones were randomly divided in to 3 groups. Group A was given intramuscular d...