The purpose of the present study was to optimize a solid lipid nanoparticle (SLN) of chloramphenicol by investigating the relationship between design factors and experimental data using response surface methodology. A Box-Behnken design was constructed using solid lipid (X(1)), surfactant (X(2)), and drug/lipid ratio (X(3)) level as independent factors. SLN was successfully prepared by a modifi...

The rate of solidification affects the microstructure, quality and mechanical properties of the castings. The analysis of heat transfer in centrifugal casting is very complex due to rapid solidification, rotating mould, opaque mould and high temperature. As the grain size is directly depending on the rate of solidification of the casting, based on grain size the rate of solidification of the ce...

Kinetin is a highly potent growth factor that is capable of delaying or preventing age-related changes of human skin fibroblasts. The purpose of this study was to develop and characterize topical kinetin-loaded emulsion gel and liposome gel formulations. Emulsion formulation was prepared using the spontaneous emulsification method. Pseudoternary phase diagram for oil/water (o/w) type emulsion w...

We present theoretical studies of syntectic and monotectic solidification scenarios. Steady-state solidification along the liquid-liquid interface in a syntectic system is considered by means of a boundary-integral technique developed previously. We study the case of small asymmetry of the pattern and extract from the results the scaling relations in terms of the undercooling and the asymmetry ...

one small-scale double emulsion technique for incorporation of naja- naja oxiana venom into poly (lactide-co-glycolide) (plga) microspheres were developed and optimized. the effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and in vitro release of venom were studied. a stable double emulsion was verified by homogenization method. slow...

A two-dimensional thermal elasto-plastic numerical model is developed by finite element method to analyze and compare the mechanical driving factor for heat affected zone (HAZ) liquation cracking during laser welding and hybrid laser-arc welding techniques. Calculations of transient temperatures and cooling rates are used in conjunction with solidification theory to analyze weld pool characteri...

A method is presented to use a dimensionless form of the well-known Niyama criterion to directly predict the amount of shrinkage porosity that forms during solidification of metal alloy castings. The main advancement offered by this method is that it avoids the need to know the threshold Niyama value below which shrinkage porosity forms; such threshold values are generally unknown and alloy dep...

Producing high-efficient, low-cost, and green water-based adhesives with enhanced bonding performance still remains highly challenging. In this study, waterborne polyurethane (WPU) adhesive films long-term stability are in situ fabricated on a metal substrate by facile high-efficiency preparation method known as demulsification-induced fast solidification (DIFS). The strength of was constructin...

The objective of this work was to introduce a novel method for refining the solidification microstructure. Traditional casting usually solidifies one homogeneous liquid by removing heat from liquid surface, by which the microstructure solely depends on the heat removal rate for the given alloy composition. The newly developed multi-liquid composite simultaneous casting concept raises an alterna...

Phenol emulsion reassociation technique (PERT) greatly enhances the rate of DNA hybridization in solution over typical hybridization conditions (1) and has successfully been used to accelerate competitive DNA reassociation for performing subtraction based genomic cloning (2-5). PERT is accomplished through the establishment and maintenance of a phenol emulsion, typically by mechanical vortexing...