Abstract The enaminone, (2 E )-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with dimethylformamide dimethylacetal (DMF–DMA) without solvent for 12 h. dihydropyrimidinone derivatives (1–9) were reacting substituted benzaldehydes and urea in glacial acetic acid. compounds synthesized significant yield using one step multicomp...

Easily obtainable cyclic enaminones (piperidin-2-ylidenealkanones) can be transformed into substituted bicyclic pyridazinium tetrafluoroborates upon treatment with corresponding diazonium salts. The transformation can be performed either in a one-pot way or in a two-step process with the isolation of single azo-coupled enaminone as the intermediate. The former method is superior. Under the opti...

BACKGROUND The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics. RESULTS A number of new heterocyclic compounds incorporating thiophene species have been prepared from the titled enaminone via the reaction with different nucleophiles and electrophiles. The structure elucidation of the designe...

Streptazone A and abikoviromycin are alkaloids that both feature an unusual arrangement of reactive functionalities within a compact tricyclic ring system. Here, we report highly concise asymmetric synthesis natural products. The route first constructs another family member, streptazone B1, using rhodium-catalyzed distal selective allene-ynamide Pauson–Khand reaction. regio- enantioselective ep...